Results 51 to 60 of about 417,841 (308)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Vectorial Formalism of Polyphase Synchronous Machine With Permanents Magnets

Aceh International Journal of Science and Technology, 2013
This paper presents a mathematical model that transforms the real machine to fictitious machines and our goal is to simulate these and see the behavior of these machines in load.
Nacéra Bachir Bouiadjra, Mohamed Abid, Mohamed B. Benabdallah, Boubakeur Dehiba, Abdelkrim Sellam, Boubakeur Bensaid, Mustapha Djouhri   +6 more
doaj  

On Linear Algebra Education [PDF]

İnönü Üniversitesi Eğitim Fakültesi Dergisi, 2009
Linear algebra is a basic course followed in mathematics, science, and engineering university departments.Generally, this course is taken in either the first or second year but there have been difficulties in teachingand learning.
Sinan AYDIN
doaj  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

O fragmentado e tortuoso processo de construção dos conceitos de vetor e escalar

Revista Brasileira de Ensino de Física
O presente trabalho é uma tentativa de chamar a atenção para a forma inadequada da construção dos conceitos de vetor e escalar apresentados na maioria dos livros de física no nível universitário.
Osman Rosso Nelson, Ranilson Carneiro Filho   +1 more
doaj   +1 more source

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Asymmetrical Six-Phase Space Vector Pwm Scheme

Mokslas: Lietuvos Ateitis, 2014
Multiphase electric motors have smaller torque pulsations and are more reliable that their three-phase alternatives. However, standard electricity grids around the world are three-phase, so power inverter is needed to drive multiphase motors. Inverter is
Tadas Lipinskis
doaj   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Countable Fuzzy Topological Space and Countable Fuzzy Topological Vector Space

Journal of Mathematical and Fundamental Sciences, 2015
This paper deals with countable fuzzy topological spaces, a generalization of the notion of fuzzy topological spaces. A collection of fuzzy sets F on a universe X forms a countable fuzzy topology if in the definition of a fuzzy topology, the condition of
Apu Kumar Saha, Debasish Bhattacharya
doaj   +1 more source