Results 121 to 130 of about 8,456 (309)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Thrust-induced effects on low-speed aerodynamics of fighter aircraft [PDF]

Results of NASA Langley has conducted wind-tunnel investigations of several fighter configurations conducted to determine the effects of both thrust vectoring and spanwise blowing are reviewed. A recent joint NASA/Grumman Aerospace Corporation/U.S.
Banks, D. W., Paulson, J. W., Jr., Quinto, P. F.   +2 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Investigation on Flow Characteristics of SVC Nozzles

Journal of Applied Fluid Mechanics, 2018
Shock vectoring control (SVC) is an important method of fluidic thrust vectoring (FTV) for aero-engine exhaust system. It behaves better on nozzle of high pressure ratio, and is considered as an alternative TV technology for a future aero-engine with ...
S. H. I. Jingwei, Z. Wang, L. Zhou, S. U. N. Xiaolin   +3 more
doaj  

Conceptual design, evaluation and research identification for Remote Augmented Propulsive Lift Systems (RALS) with ejectors for VTOL aircraft [PDF]

Ejector concepts for use with a remote augmented lift system (RALS) exhaust nozzle were studied. A number of concepts were considered and three were selected as having the greatest promise of providing the desired aircraft and exhaust gas cooling and ...
Konarski, M., Sutherland, M. V., Willis, W. S.   +2 more
core   +1 more source

Auto-tuning for high performance autopilot design [PDF]

, 2010
A novel auto-tuning method for the RIDE controller algorithm is presented. The RIDE controller is applied to a high performance aircraft model. The tuner utilises a constrained genetic algorithm to automate the tuning process.
Brindley, Joseph, Counsell, J.M., Zaher, O.S.   +2 more
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Evaluation of Four Advanced Nozzle Concepts for Short Takeoff and Landing Performance [PDF]

Four advanced nozzle concepts were tested on a canard-wing fighter in the Langley 14- by 22-Foot Subsonic Tunnel. The four vectoring-nozzle concepts were as follows: (1) an axisymmetric nozzle (AXI); (2) an asymmetric, load balanced exhaust nozzle (ALBEN)
Kemmerly, Guy T., Paulson, John W., Jr., Quinto, P. Frank   +2 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Thrust Vectoring Control for Heavy UAVs, Employing a Redundant Communication System. [PDF]

Sensors (Basel), 2023
Ale Isaac MS, Ragab AR, Luna MA, Ale Eshagh Khoeini MM, Campoy P.   +4 more
europepmc   +1 more source