Results 81 to 90 of about 8,456 (309)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A comprehensive review on intelligent torque vectoring control for electric vehicle

Energy Exploration & Exploitation
Vehicle dynamic control (VDC) is an important study where the vehicle performance, handling, stability, and statistics of the vehicle can be recorded to improve performance.
F Vanlalhriatpuia, Ksh Robert Singh, Amarendra Matsa, Subir Datta, Md. Minarul Islam, Taha Selim Ustun   +5 more
doaj   +1 more source

Torque Vectoring Control as an Energy-Efficient Alternative to Vehicle Suspensions Tuning

Energies
With a shift in the automotive industry’s focus towards sustainability and energy efficiency, optimizing vehicle handling dynamics has been put on a secondary level.
Michele Asperti, Michele Vignati, Edoardo Sabbioni   +2 more
doaj   +1 more source

Design of thrust vectoring exhaust nozzles for real-time applications using neural networks [PDF]

Thrust vectoring continues to be an important issue in military aircraft system designs. A recently developed concept of vectoring aircraft thrust makes use of flexible exhaust nozzles.
Markin, Robert E., Prasanth, Ravi K., Whitaker, Kevin W.   +2 more
core   +1 more source

On the hardware reduction of z-datapath of vectoring CORDIC

, 2007
In this article we present a novel design of a hardware optimal vectoring CORDIC processor. We present a mathematical theory to show that using bipolar binary notation it is possible to eliminate all the arithmetic computations required along the z ...
Maharatna, Koushik, Matthew, Jimson, Nunez-Yanez, Jose, Pradhan, Dhiraj, Stapenhurst, Robert   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Multiaxis thrust vectoring using axisymmetric nozzles and postexit vanes on an F/A-18 configuration vehicle [PDF]

A ground-based investigation was conducted on an operational system of multiaxis thrust vectoring using postexit vanes around an axisymmetric nozzle.
Bowers, Albion H., Grafton, Sue B., Mason, Mary L., Noffz, Gregory K., Peron, Lee R.   +4 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Thrust vectoring for lateral-directional stability [PDF]

The advantages and disadvantages of using thrust vectoring for lateral-directional control and the effects of reducing the tail size of a single-engine aircraft were investigated.
Carpenter, Thomas, Peron, Lee R.
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source