Results 31 to 40 of about 1,772 (183)

Review Article: The Impact of the Gut Microbiome on Ulcerative Colitis Pharmacotherapy

Alimentary Pharmacology &Therapeutics, EarlyView.
The gut microbiome modulates ulcerative colitis pharmacotherapy through microbial drug metabolism, immune regulation and altered drug bioavailability. Microbial composition influences response to aminosalicylates, corticosteroids, immunomodulators, biologics and small molecules, while microbiome‐targeted therapies show emerging promise.
Kate Collins, Srinivas Kamath, Rachel H. Davis, Samuel P. Costello, Robert V. Bryant, Alice S. Day, Paul Joyce   +6 more
wiley   +1 more source

From Līlā to Nitya and Back: Śrī Rāmakṛṣṇa and Vedānta

Religions, 2020
There has been a long-standing academic debate on the religious orientation of Śrī Rāmakṛṣṇa Paramahaṁsa (1836–1886), one of the leading religious figures of modern India.
Arpita Mitra
doaj   +1 more source

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

Theologies of Mind: Eriugena and Pratyabhijñā Śaivism

Modern Theology, EarlyView.
Abstract Though Eriugena's affinities with several Hindu traditions are clear, this article offers to my knowledge the first detailed discussion of Eriugena's theology in relation to any Indic theological school, here, the nondualist Śaiva tradition known as the Pratyabhijñā (“Recognition”) lineage.
Matthew Z. Vale
wiley   +1 more source

Introduction: Charting the Evolution of English and Anglophone Writing in Asia

World Englishes, EarlyView.
ABSTRACT This introductory article explores the history of the English language and literatures in the Asian ‘Outer Circle’ countries, or English in its ‘second diaspora’, focusing primarily on literature from its beginnings to the present. Due to space limitations, the scope is further narrowed to poetry and the novel – the two genres that, arguably ...
Mohammad A. Quayum
wiley   +1 more source

Deprescribing in Elderly Diabetes: Integrating Clinical Practice with Vedantic Wisdom

Journal of the Indian Academy of Geriatrics
Background: The growing burden of type 2 diabetes (T2D) in older adults, particularly in low-and middle-income countries like India, has intensified concerns around polypharmacy, adverse drug events, and inappropriate prescribing.
Shambo Samrat Samajdar, Shashank R. Joshi, Minakshisundaram Shunmugavelu, Shatavisa Mukherjee, Alok Modi, Banshi Saboo, Anuj Maheshwari, Arvind Mathur   +7 more
doaj   +1 more source

Global Roll‐Out and Continued Multi‐Site Validation of the Artificial Intelligence Histology Instrument for Qualitative Assessment of Histopathology in Ulcerative Colitis

United European Gastroenterology Journal, Volume 14, Issue 6, July 2026.
ABSTRACT Background Histological assessment of mucosal biopsies in patients with ulcerative colitis (UC) can determine the activity and extent of disease and assess response to treatment. However, its widespread adoption is limited by the time required for the advanced GI specialty training to handle and review histopathology digital images, inter‐ and
Laurent Peyrin‐Biroulet, Olga Kubassova, Jon Himoff, Christopher R. Weber, Shashi Adsul, Marcelo Freire, Bader E. Hussaini, Luc Biedermann, Viktor H. Koelzer, Brian Bressler, Wei Xiong, Jan H. Niess, Matthias S. Matter, Uri Kopylov, Iris Barshack, Chen Mayer, Fernando Magro, Fatima Carneiro, Nitsan Maharshak, Ariel Greenberg, David T. Rubin   +20 more
wiley   +1 more source

Factors associated with acute medication overuse in people with migraine: results from the 2017 migraine in America symptoms and treatment (MAST) study

The Journal of Headache and Pain, 2018
Background The MAST Study is a longitudinal, cross-sectional survey study of US adults with migraine. These analyses were conducted to estimate rates of acute medication overuse (AMO) and determine associations of AMO with individual and headache ...
Todd J. Schwedt, Aftab Alam, Michael L. Reed, Kristina M. Fanning, Sagar Munjal, Dawn C. Buse, David W. Dodick, Richard B. Lipton   +7 more
doaj   +1 more source

Clinical Trial: Predicting Response to Iron Therapy in Patients With Active Inflammatory Bowel Disease Using Hepcidin and Functional Iron Indices: A Multicentre Randomised Trial

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 2, Page 166-176, July 2026.
Hepcidin levels predict response to iron therapy and support route selection for iron therapy in patients with active inflammatory bowel disease: higher levels favour IV iron, while lower levels indicate likely oral response. Ferritin‐based indices, particularly transferrin/log10(ferritin) and sTfR/log10(ferritin), offer reliable alternatives. ABSTRACT
Lola J. M. Koppelman, Roberta Loveikyte, Rogier L. Goetgebuer, Sander van der Marel, Annemarie C. de Vries, Gerard Dijkstra, Andrea E. van der Meulen‐de Jong, on behalf of the Dutch Iron Study Group, M. Duijvestein, M. van der Have, C. Horjus, W. G. N. Mares, Z. Mujagic, B. Oldenburg, R. West   +14 more
wiley   +1 more source

Rezafungin Versus Caspofungin in Candidaemia and Invasive Candidiasis: A Post Hoc Pooled Analysis of Phase 2 and Phase 3 Trials

Mycoses, Volume 69, Issue 7, July 2026.
ABSTRACT Background The efficacy and safety of rezafungin in invasive candidiasis (IC) and candidaemia was demonstrated in the Phase 2 STRIVE and Phase 3 ReSTORE trials, and an additional cohort of patients in ReSTORE from China (ReSTORE China). Objectives This post hoc analysis is the first time that combined data from all double‐blind, randomised ...
Alex Soriano, George R. Thompson III, Oliver A. Cornely, Matteo Bassetti, Bart Jan Kullberg, Patrick M. Honoré, Hervé Dupont, Jose A. Vazquez, Haihui Huang, Yingyuan Zhang, Sara Dickerson, Laura Cox, Peter G. Pappas   +12 more
wiley   +1 more source