Results 41 to 50 of about 15,943 (150)

Long‐term outcomes of children with ulcerative colitis after acute severe colitis: A GETAID pédiatrique multicenter study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti–tumor necrosis factor (anti‐TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric‐onset UC patients after ASC.
Manon Cochet, Agathe Beauvais, Frank Ruemmele, Raphael Enaud, Thierry Lamireau, Rémi Duclaux‐Loras, Claire Dupont, Stéphanie Willot, Laure Bridoux‐Henno, Georges Dimitrov, Julie Lemale, Vincent Guinard‐Samuel, Valérie Bertrand, Anne Breton, Christine Martinez Vinson, Stéphanie Coopman, Delphine Ley, Bénédicte Pigneur, and the Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du tube Digestif (GETAID) pédiatrique   +18 more
wiley   +1 more source

Structural specializations of \(\alpha_4 \beta_7\), an integrin that mediates rolling adhesion [PDF]

, 2012
The lymphocyte homing receptor integrin \(\alpha_4 \beta_7\) is unusual for its ability to mediate both rolling and firm adhesion. \(\alpha_4 \beta_1\) and \(\alpha_4 \beta_7\) are targeted by therapeutics approved for multiple sclerosis and Crohn’s ...
Chen, JianFeng, Mi, Li-Zhi, Springer, Timothy A., Sun, Hao, Walz, Thomas, Yu, Yamei, Zhu, Jianghai   +6 more
core   +1 more source

Responsible laboratory surveillance of pediatric patients with inflammatory bowel disease on biologic infusion therapy

JPGN Reports, EarlyView.
Abstract The annual healthcare spending on pediatric inflammatory bowel disease (IBD) has increased over time. The objectives of the study were to investigate the cost of routine laboratory surveillance in pediatric IBD patients during outpatient maintenance biologic infusions and determine their impact on clinical management.
Tanmai Shah, Ashwin Agrawal, Héctor E. Alcalá, Anupama Chawla   +3 more
wiley   +1 more source

PDB140 Quality of Care For Patients With Diabetes Mellitus (Dm) In Canada: Findings From A National Population-Based Survey [PDF]

, 2008
Núm. de Catàleg de Patrimoni: 2076Primer pla d'una operària netejant una troballa d'estris de metall, a les excavacions realitzades sota el pis de la Sala Capitular del Monestir de Santa Maria de Pedralbes des de finals de 2007 i fins a principis de ...
Szabo, SM, Balijepalli, C, Cheung, A, Johnston, KM   +3 more
core   +1 more source

Efficacy of upadacitinib induction for pediatric inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Objectives Upadacitinib, a second‐generation Janus kinase (JAK) inhibitor, is approved for moderate to severe Crohn's disease (CD) and ulcerative colitis (UC) in adults. Its efficacy in pediatric patients remains unclear, though early reports suggest benefits in refractory inflammatory bowel disease (IBD).
Evan Greenhall, Nina Gautam, Paula Prieto‐Jimenez, Elizabeth Hilow, Ashish Patel, Brad Pasternak   +5 more
wiley   +1 more source

Animal models of ulcerative colitis and their application in drug research [PDF]

, 2014
The specific pathogenesis underlying inflammatory bowel disease is complex, and it is even more difficult to decipher the pathophysiology to explain for the similarities and differences between two of its major subtypes, Crohn’s disease and ulcerative ...
Low, Daren, Mizoguchi, Emiko, Nguyen, Deanna D   +2 more
core   +1 more source

Leukocytoclastic vasculitis and necrobiotic pulmonary nodules in endoscopic remission of ulcerative colitis

JPGN Reports, EarlyView.
Abstract Skin and lung findings, including the rare findings of leukocytoclastic vasculitis (LCV) and necrobiotic pulmonary nodules, are known extraintestinal manifestations (EIMs) of inflammatory bowel disease. However, these rare EIMs have typically been reported as being a sign of active intestinal disease.
Joshua D. Noe, James Bistolarides, Karolyn A. Wanat, Yvonne Chiu   +3 more
wiley   +1 more source

An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors [PDF]

, 2019
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium ...
Au, L, Chauhan, D, Edmonds, K, Gore, M, Hughes, P, Husson, O, Lai, Z, Larkin, J, Lingard, K, Ludlow, A, Lynch, J, Mann, J, Mclean, E, O'Reilly, A, Pattison, N, Teh, JJ, Turajlic, S, Wiseman, T   +17 more
core   +3 more sources

Benralizumab for anti‐tumor necrosis factor‐associated eosinophilic gastrointestinal disease in a child with ileal Crohn's: A case report

JPGN Reports, EarlyView.
Abstract Crohn's disease (CD) and eosinophilic gastrointestinal diseases (EGIDs) are distinct inflammatory entities, but eosinophilic disease may emerge as a paradoxical immune complication of anti–tumor necrosis factor therapy. We report a 12‐year‐old boy with terminal ileal CD who developed severe eosinophilic gastritis and ileitis, peripheral ...
Jonathan Dudzik, Alberto Pinzon‐Charry, Peter Lewindon, Fariha Balouch   +3 more
wiley   +1 more source

Gut inflammation: current update on pathophysiology, molecular mechanism and pharmacological treatment modalities [PDF]

, 2014
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory condition of the gastrointestinal tract. The two main forms of IBD are Crohn's disease and ulcerative colitis. According to the recent concept the disease is caused by a combination
Gyires, Klára, Tóth, Viktória, Zádori, Zoltán Sándor   +2 more
core   +1 more source