Results 101 to 110 of about 105,678 (266)

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Efficient energy management and cost optimization using multi-objective grey wolf optimization for EV charging/discharging in microgrid

e-Prime: Advances in Electrical Engineering, Electronics and Energy
The depletion of conventional energy sources coupled with the rising demand for electric vehicles (EVs) has significantly underscored the necessity for electric vehicle supply equipment (EVSE) with advanced energy supply management within microgrids ...
Swati Sharma, Ikbal Ali
doaj   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Reconstruction of Ultrafine MnS‐Induced Vacancy‐Rich Co9S6.29 Precatalysts in Mesoporous S‐Doped N‐Rich Hollow Carbon Nanotubes Enables Dynamic O‐Vacancy Cycling for High‐Performance Zn‐Air Batteries

Advanced Science, EarlyView.
We develop vacancy‐rich Co9S6.29 precatalysts formed via ultrafine MnS‐induced lattice distortion in mesoporous S‐doped N‐rich hollow carbon nanotubes (CM@SNHCTs). This CM@SNHCT precatalyst is reconstructed into catalytically‐active cathode phases that enable efficient oxygen reduction/evolution reactions (ORR/OER) through dynamic O‐vacancy formation ...
Debarani Devi Khumujam, Saleem Sidra, Ram Babu Ghising, Dong Won Kim, Jong Hui Choi, Gwanho Lee, Benzhi Wang, Hyung Mo Jeong, Sang‐Il Choi, Do Hwan Kim, Jeung Ku Kang   +10 more
wiley   +1 more source

Revealing the Ion Regulation Effect of Zwitterionic All‐Solid‐State Electrolytes in Lithium Metal Batteries

Advanced Science, EarlyView.
This study investigates zwitterionic all‐solid‐state electrolytes, demonstrating strong carboxyl‐Li+ interaction that forms “ion‐enrichment pathway”‐like domains and manipulates Li+ deposition. Additionally, surface‐enriched zwitterions generate a dual‐layer SEI with an inner Li2O‐rich and outer LiF‐rich structure. Through ionic flux regulation and SEI
Wentao Xie, Yu Wu, Yierfan, Yuling Yang, Dongdong Gao, Liangbo Xu, Luoman Qin, Xingyu Lu, Yinjuan Chen, Changle Mu, Danyu Gu, Chunlei Wei, Yi He, Gang Cheng   +13 more
wiley   +1 more source

Strain‐Adaptive Dielectric Metamaterials via Bioinspired “Ligament‐Bone” Architecture for Ultrahigh‐Energy Capacitive Storage

Advanced Science, EarlyView.
A bioinspired strain‐adaptive ligament‐bone architecture achieves record‐high energy density of 26.1 J cm−3 and 90% efficiency at 600 MV m−1, coupled with a Young's modulus of 2.13 GPa. ABSTRACT Polymer dielectrics for capacitive energy storage face fundamental trade‐offs between breakdown strength, energy density, efficiency, and mechanical robustness.
Jian Wang, Xinyu Wang, Jiabao Wang, Biyun Peng, Yifei Zhang, Ning Zhu, Xin Hu   +6 more
wiley   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Interfacial Growth of 420 nm Ultrathin and Dense MOFs for Composite Electrolyte to Reduce Li+ Conduction Resistance and Inhibit Lithium Dendrite

Advanced Science, EarlyView.
In this work, an interfacial growth method using PVDF‐HFP enables controlled permeation of 2‐methylimidazole to react with Co2+, forming an ultrathin (420 nm) ZIF‐67 layer by precisely tuning the reaction time. This dense layer promotes lithium salt dissociation and suppresses dendrite growth, while its ultrathin nature reduces Li+ transport resistance,
Xinhong Qi, Zhaokai Rui, Shichen Zhang, Yihang Li, Ziyi Xin, Mengjuan Li, Lu Gao, Yuchen He, Xiaobin Jiang, Xiangcun Li, Gaohong He   +10 more
wiley   +1 more source