Results 51 to 60 of about 29,524 (312)

SavingsAnts for the Vehicle Routing Problem

, 2002
In this paper we propose a hybrid approach for solving vehicle routing problems. The main idea is to combine an Ant System (AS) with a problem specific constructive heuristic, namely the well known Savings algorithm. This differs from previous approaches, where the subordinate heuristic was the Nearest Neighbor algorithm initially proposed for the TSP.
Karl Doerner, Manfred Gronalt, Richard F. Hartl, Marc Reimann, Christine Strauss, Michael Stummer   +5 more
openaire   +5 more sources

Disruption management of the vehicle routing problem with vehicle breakdown [PDF]

, 2011
This paper introduces a new class of problem, the disrupted vehicle routing problem (VRP), which deals with the disruptions that occur at the execution stage of a VRP plan.
Eglese, R W, Mu, Q, Fu, Z, Lysgaard, J
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Status update frequency optimization for In-vehicle LAN route based on deep Q-learning

Results in Control and Optimization, 2022
The popularization of the automated fleet requires a reliable transmission of In-vehicle Local Area Network (LAN) with high mobility under complex environment. Therefore, In-vehicle communication system needs to collect the network status of the vehicles
Yaowen Qi, Qilong Huang, Li Yang, Cangqi Zhou, Chengsheng Pan   +4 more
doaj   +1 more source

Investigation of routing reliability of vehicular ad hoc networks [PDF]

, 2013
In intelligent transportation systems, the cooperation between vehicles and the road side units is essential to bring these systems to fruition. Vehicular ad hoc networks (VANETs) are a promising technology to enable the communications among vehicles on ...
Eiza, MH, Owens, T, Eiza, M.H., Mahmoud Hashem Eiza, Qiang Ni, Owens, T., Min, Geyong, Geyong Min, Owens, Thomas, Ni, Q, Hashem Eiza, M, Ni, Qiang, Ni, Q., Eiza, Mahmoud, Min, G, Thomas Owens   +15 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Optimal multi-depot location decision using particle swarm optimization

Advances in Mechanical Engineering, 2017
The depot locations have a significant effect on the transportation cost in the multi-depot vehicle routing problem. A two-tier particle swarm optimization framework is proposed, in which an external particle swarm optimization and an internal particle ...
Yin-Mou Shen, Ruey-Maw Chen
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Recycling of NiTi Shape Memory Alloys: Fundamental and Technological Aspects of a Vacuum Induction Melting Processing Route

Advanced Engineering Materials, EarlyView.
The present study investigates recycling of NiTi shape memory alloys via vacuum induction melting. An ingot was synthesized from elemental Ni and Ti and subjected to three subsequent remelting cycles. Remelting increases process durations and impurity levels and adversely affects microstructures and functional properties.
Sakia Sophia Noorzayee, Son Tung Mai, Sarath Menon, Braulio Gadiel Sánchez Ortega, Ralf Drautz, Alexander Kauffmann, Gunther Eggeler, Jan Frenzel   +7 more
wiley   +1 more source