Results 101 to 110 of about 6,468,160 (286)

The Pyramidal Capacitated Vehicle Routing Problem [PDF]

This paper introduces the Pyramidal Capacitated Vehicle Routing Problem (PCVRP) as a restricted version of the Capacitated Vehicle Routing Problem (CVRP).
Lysgaard, Jens
core  

Targeted Multifunctional Fluorine‐Rich Copolymer Coating Design for Ambient‐Stable Prelithiated SiOC Anodes

Advanced Science, EarlyView.
A fluorine‐rich acrylate copolymer, poly (tridecafluorooctyl methacrylate‐co‐methyl methacrylate) (PFMMA), is introduced as a multifunctional protective coating to stabilize the prelithiated SiOC electrodes in humid conditions and preserve unimpeded interfacial ion/charge transport during redox reactions.
Rong Chen, Yixuan Fan, Congcong Zhang, Yinan Liu, Yun Zheng, Ruifeng Zheng, Yingying Shen, Pingshan Jia, Luojiang Zhang, Yongbing Tang, Huaiyu Shao   +10 more
wiley   +1 more source

Enhancing heuristic bubble algorithm with simulated annealing

Cogent Business & Management, 2016
In this study, a new way to improve the Heuristic Bubble Algorithm (HBA) is presented. HBA is a nature-inspired algorithm, which is a new approach to and initially implemented for, vehicle routing problems of pickup and delivery (VRPPD).
Mehmet Fatih Yuce, Erhan Musaoglu, Ali Gunes   +2 more
doaj   +1 more source

The Case Study of Implementing the Delivery Optimization System at a Fast-Moving Consumer Goods Distributer

Promet (Zagreb), 2013
Using new optimization methods and information-communications technology has become the key issue in the competition among the distributers of fast-moving consumer goods.
Ante Galić, Tonči Carić, Juraj Fosin
doaj   +1 more source

The Vehicle Rescheduling Problem [PDF]

The capacitated vehicle routing problem is to find a routing schedule describing the order in which geographically dispersed customers are visited to satisfy demand by supplying goods stored at the depot, such that the traveling costs are minimized.
Dekker, R., Spliet, R., Gabor, A.F.
core  

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

A savings based method for real-life vehicle routing problems [PDF]

This paper describes a Savings Based algorithm for the Extended Vehicle Routing Problem. This algorithm is compared with a Sequential Insertion algorithm on real-life data.
Wagelmans, A.P.M., Poot, A., Kant, G.
core  

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Reachability cuts for the vehicle routing problem with time windows [PDF]

This paper introduces a class of cuts, called reachability cuts, for the Vehicle Routing Problem with Time Windows (VRPTW). Reachability cuts are closely related to cuts derived from precedence constraints in the Asymmetric Traveling Salesman Problem ...
Lysgaard, Jens
core