Results 31 to 40 of about 1,303,176 (294)

Dynamic Modeling Method of Mission Reliability of a Multi-State Manufacturing System With Multiple Production Lines

open access: yesIEEE Access, 2020
Mission reliability could systematically characterize the running state of a manufacturing system and the rationality of production task setting in advance.
Yijing Zhang   +5 more
doaj   +1 more source

Vibration Suppression of Railway Vehicle Carbody with Piezoelectric Elements

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2007
Piezoelectric elements, which are electrically connected to external shunt circuits, are introduced to suppress bending vibration of a scale model of a railway vehicle. The authors proposed two types of shunt circuits aiming at practical use. One circuit
Tadao TAKIGAMI   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The impact of driving conditions on light-duty vehicle emissions in real-world driving

open access: yesTransport, 2020
To accurately estimate the effect of driving conditions on vehicle emissions, an on-road light-duty vehicle emission platform was established based on OEM-2100TM, and each second data of mass emission rate corresponding to the driving conditions were ...
Dong Guo   +6 more
doaj   +1 more source

Assessment of Health Indicators to Detect the Aging State of Commercial Second-Life Lithium-Ion Battery Cells through Basic Electrochemical Cycling

open access: yesBatteries, 2023
Upon reaching certain limits, electric vehicle batteries are replaced and may find a second life in various applications. However, the state of such batteries in terms of aging and safety remains uncertain when they enter the second-life market.
Emanuele Michelini   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Research on dynamic path planning method of moving single target based on visual AGV

open access: yesSN Applied Sciences, 2022
In order to research the ability of AGV to cope with the dynamic path planning in mobile single-object dynamic environment, the dynamic path planning methods based on reduced point and non-reduced point were proposed.
Meng Sun   +4 more
doaj   +1 more source

Safety Assessment of High Dynamic Pre-Loaded Lithium Ion Pouch Cells

open access: yesBatteries, 2023
The knowledge of the influence of high dynamic loads on the electrical and mechanical behavior of lithium-ion cells is of high importance to ensure a safe use of batteries over the lifetime in electric vehicles.
Christian Ellersdorfer   +4 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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