Results 111 to 120 of about 3,875,323 (288)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A Systematic Review of Thermal Runaway in Li-ion Batteries: Pathways, Detection Techniques, and Early Warning Models

Future Batteries
In the recent past, various accidents related to lithium battery fires have been reported worldwide, some of them being fatal. This emphasizes the need to improve battery systems’ safety for their users.
Shubham Bhoir, Emanuele Michelini, Jörg Moser, Claudio Brivio, Mario Paolone   +4 more
doaj   +1 more source

How “International” Should a Third Conflicts Restatement Be in Tort and Contract? [PDF]

, 2013
The main goal of this work is to gain knowledge of how and to what extent state-of-the-artsimulation tools can be used in a conceptual development phase for vehicle dynamics control atVolvo Car Corporation (VCC).The first part of the thesis deals with an
Gurov, Alexey, Sengupta, Abhinav
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Automated Merging in a Cooperative Adaptive Cruise Control (CACC) System [PDF]

, 2011
Cooperative Adaptive Cruise Control (CACC) is a form of cruise control in which a vehicle maintains a constant headway to its preceding vehicle using radar and vehicle-to-vehicle (V2V) communication.
Heijenk, Geert, Karagiannis, Georgios, Klein Wolterink, Wouter   +2 more
core   +3 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Bidirectional Power Flow between Solar-Integrated Grid to Vehicle, Vehicle to Grid, and Vehicle to Home

Journal of Applied Science and Engineering
The increasing adoption of renewable energy sources, such as solar power, coupled with the growing popularity of electric vehicles (EVs), has opened up new opportunities for bidirectional power flow between various energy systems.
Swarupa Rani Bondalapati, Baddu Naik Bhukya, G.V. Prasanna Anjaneyulu, Manam Ravindra, B. Sarath Chandra   +4 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

A Grid-Compatible Adaptive Charging Strategy for Bidirectional On-Board EV Chargers with SOC and Thermal Integration

Power Electronics and Drives
This paper presents a novel adaptive charging strategy for a three-phase bidirectional on-board electric vehicle (EV) charger. The charger system enables seamless grid-to-vehicle (G2V) and vehicle-to-grid (V2G) operations while enhancing battery ...
Omkar Malleni, Kumar M Vijaya
doaj   +1 more source