Results 151 to 160 of about 118,202 (332)

Anti‐Inflammatory Effects of Flavonoids in Otitis Media: A Systematic Review of Pre‐Clinical Evidence

open access: yesFood Frontiers, EarlyView.
Otitis media (OM) is a middle ear infection driven by chronic inflammation, leading to tissue damage and complications such as cholesteatoma. Flavonoids, a class of polyphenols with anti‐inflammatory properties, suppress key inflammatory mediators, reducing neutrophilic infiltration and mucosal thickening. These findings suggest flavonoids as potential
Madiha Ajaz   +3 more
wiley   +1 more source

Endoplasmic Reticulum Stress Amplifies Cytokine Responses in Astrocytes via a PERK/eIF2α/JAK1 Signaling Axis

open access: yesGlia, EarlyView.
ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri   +8 more
wiley   +1 more source

Wireless Communications for Vehicular Ad-Hoc Networks

open access: yes, 2014
In this chapter, we present a novel theoretical framework suitable for analytical performance evaluation of a family of multihop broadcast protocols. The framework allows to derive several average performance metrics, including reliability, latency, and efficiency, and it is targeted to Vehicular Ad-hoc NETworks (VANETs) applications based on an ...
Picone M.   +4 more
openaire   +4 more sources

A reciprocal interaction between L‐lysine and Holdemanella biformis modulates intestinal barrier function and anxiety in irritable bowel syndrome

open access: yesiMetaOmics, EarlyView.
This study uncovers a complex interaction between l‐lysine and Holdemanella biformis (H. biformis) in irritable bowel syndrome (IBS). l‐lysine enhances intestinal barrier function and alleviates anxiety‐like behaviours by modulating tryptophan metabolism. In contrast, H. biformis improves gut barrier integrity but exacerbates anxiety‐like behaviours. H.
Chun‐Hui Jiang   +9 more
wiley   +1 more source

A gut microbiota‐bile acid axis inhibits the infection of an emerging coronavirus by targeting its cellular receptor aminopeptidase N

open access: yesiMeta, EarlyView.
Bacteroides fragilis employs bile salt hydrolase to reprogram host bile acid metabolism, generating lithocholic acid that directly blocks porcine deltacoronavirus infection by disrupting spike protein‐aminopeptidase N binding, defining a microbiota‐bile acid antiviral axis with therapeutic potential against coronaviruses.
Ya‐Qing Zhang   +12 more
wiley   +1 more source

RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling

open access: yesiMeta, EarlyView.
This study proposes an innovative therapeutic approach by combining RRM2 gene knockout with a nanocarrier system, significantly enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma. The study developed a tumor microenvironment‐responsive nanosystem that achieves synergistic effects through SPIO‐mediated and RRM2 knockout ...
Weiliang Hou   +19 more
wiley   +1 more source

A framework for Broker placement in vehicular ad hoc Networks [PDF]

open access: green, 2012
Laura K. Poff   +2 more
openalex   +1 more source

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