Results 181 to 190 of about 118,202 (332)

Nasal Delivery of mRNA Using Thermoresponsive Gellable Aqueous Biphasic Systems

open access: yesSmall, EarlyView.
Nasal delivery of mRNA using gellable aqueous biphasic systems (ABS) represents a noninvasive alternative while reducing the need for trained professionals and cold chain storage. Composed of gelatin, PEG, and water, these thermoresponsive hydrogels ensure controlled mRNA delivery and prolonged retention at the nasal mucosa, improving transfection ...
Bojan Kopilovic   +4 more
wiley   +1 more source

Targeted Delivery of miR‐34a via Anti‐CD47 Antibody Conjugates for Enhanced Cancer Immunotherapy in Triple Negative Breast Cancer

open access: yesSmall, EarlyView.
aCD47‐C‐miR34a, an antibody‐oligonucleotide platform combining an anti‐CD47 antibody with miR‐34a, is designed for targeted therapy in TNBC. This approach improved delivery and restored the tumor‐suppressing function of miR‐34a, enhanced CD8+ T‐cell activation, and inhibited tumor growth, providing a potential strategy to overcome immune evasion and ...
Youngri Ryu   +11 more
wiley   +1 more source

In situ Synchrotron X‐ray Metrology Boosted by Automated Data Analysis for Real‐time Monitoring of Cathode Calcination

open access: yesSmall Methods, EarlyView.
An automated approach is developed for fast “on‐the‐fly” analysis of the massive data generated from in situ synchrotron X‐ray metrology during the calcination of cathode active materials (CAMs). Expanding this data‐powered platform paves the way for real time monitoring and predictive control of the calcination process, ensuring the production of CAMs
Ruhil Dongol   +13 more
wiley   +1 more source

Comprehensive Osteosarcoma Treatment with Multifunctional Composite Hydrogels Enabling Combined Photothermal Cancer Ablation and Osteoinductive Tissue Regeneration

open access: yesSmall Methods, EarlyView.
This study presents a comprehensive strategy for treating osteosarcoma and promoting bone tissue regeneration using a multifunctional composite hydrogel composed of mineralized fibers with polyphenols. Furthermore, the biomaterial effectively mitigates the degenerative microenvironment including oxidative stress that develops after tumor ablation. This
Hayeon Byun   +8 more
wiley   +1 more source

Impact of Acute and Sub‐Acute Gluten Exposure on Gastrointestinal Symptoms and Psychological Responses in Non‐Coeliac Gluten Sensitivity: A Randomised Crossover Study

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Background/Aims Non‐coeliac gluten sensitivity (NCGS) is a controversial entity, characterised by symptom improvement with gluten exclusion in the absence of coeliac disease. We primarily investigated the effects of acute and sub‐acute gluten on psychological and mood profiles, with secondary outcomes examining gastrointestinal symptoms and ...
Julie Iven   +5 more
wiley   +1 more source

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