Results 221 to 230 of about 48,405 (313)

Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis

open access: yesSmall, EarlyView.
This work investigates the role of collagen I signaling in the fibrotic barrier to macromolecular drug delivery in pancreatic cancer. Mechanistic analyses revealed the involvement of the receptor tyrosine kinase DDR1 signaling through PI3K/AKT/mTOR.
Mayu Ohira   +14 more
wiley   +1 more source

Novel Wide‐Spectrum Virucidal Lipid Nanoparticles

open access: yesSmall, EarlyView.
POSTAN is a novel broad‐spectrum antiviral nanoparticle that combines safety with potent virucidal activity. Composed of biocompatible lipids, it mimics heparan sulfate proteoglycans and lipid rafts exploited by viruses, thereby dismantling viral envelopes and blocking replication.
Yugo Araújo Martins   +10 more
wiley   +1 more source

Multifunctional Porous Microshuttles as Scaffolding Components and Carriers of Bioactive Factors in Self‐Assembled Microtissues

open access: yesSmall, EarlyView.
This study introduces multifunctional, bioactive factor‐loaded porous microshuttles fabricated via a one‐step emulsification and chemical etching method. The poly(lactic‐co‐glycolic acid) microshuttles, featuring tunable pore sizes, enable loading and release of bioactive factors, and thereby enhance osteogenic marker expression and promote endothelial
Ke Song   +5 more
wiley   +1 more source

Development of vehicular ad hoc network routing protocols using the click modular router [PDF]

open access: yes, 2009
Bergs, Johan   +5 more
core  

Andrias Davidianus Peptide Hydrogel Enables Sustained SR9011 Release to Promote Efferocytosis and Alleviate Colitis

open access: yesSmall, EarlyView.
NR1D1 suppresses epithelial CD47 transcription to promote efferocytosis by macrophages. In UC, NR1D1 expression is diminished, leading to CD47 upregulation, inhibition of apoptotic cell clearance, and exacerbation of intestinal inflammation. Restoring rhythmic NR1D1 activation using SR9011‐loaded bioadhesive hydrogel enhances efferocytosis, improves ...
Yidong Chen   +7 more
wiley   +1 more source

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