Results 221 to 230 of about 118,202 (332)

Norms Over Threats and Trends: A Managerial Perspective on the Role of Normative Pressures in Motivating Sustainable Strategies and Positive Outcomes

open access: yesBusiness Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT This study investigates the effectiveness of institutional pressures in motivating two contrasting sustainability strategies, symbolic and substantive, and their subsequent impact on the triple bottom line (TBL). Using data from 388 US supply chain professionals, this research applies institutional theory and structural equation modeling to ...
Alina Marculetiu   +2 more
wiley   +1 more source

Blockade of cannabinoid CB1 receptors potentiates the anti‐fibrotic effects mediated by SGLT2 inhibition in a mouse model of diabetic nephropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and purpose Diabetic nephropathy (DN) is a common complication of diabetes. Current treatments include renin‐angiotensin‐aldosterone system (RAAS) blockers and sodium‐glucose co‐transporter 2 (SGLT2) inhibitors. The cannabinoid CB1 receptor is a potential therapeutic target.
Océane Pointeau   +20 more
wiley   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto   +16 more
wiley   +1 more source

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li   +13 more
wiley   +1 more source

A Survey on Sybil Attack in Vehicular Ad-hoc Network

open access: bronze, 2014
Deepak Kushwaha   +2 more
openalex   +1 more source

Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target acute myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations (KMT2A‐r AML).
Yoana Arroyo‐Berdugo   +11 more
wiley   +1 more source

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