Results 271 to 280 of about 48,405 (313)

Second Attempt at America First: Donald Trump and the Survival of International Organizations

open access: yesGlobal Policy, EarlyView.
ABSTRACT The second Trump administration poses an existential challenge to many international organizations (IOs), putting them at risk of no longer being able to perform their core functions. Compared to the first term, the scope of America First is much wider and the speed much faster.
Hylke Dijkstra
wiley   +1 more source

Leveraging machine learning and accelerometry to classify animal behaviours with uncertainty

open access: yesMethods in Ecology and Evolution, EarlyView.
Abstract Animal‐worn sensors have revolutionised the study of animal behaviour and ecology. Accelerometers, which measure changes in acceleration across planes of movement, are increasingly being used in conjunction with machine learning models to classify animal behaviours across taxa and research questions.
Medha Agarwal   +4 more
wiley   +1 more source

Human Umbilical Cord Plasma Metabolomics Uncover Potential Metabolites for Combating Aging

open access: yesAging Cell, EarlyView.
Untargeted metabolomics reveals a unique cord plasma metabolic landscape versus adult. Age‐declining cord‐specific enriched metabolites are identified as antiaging candidates, with a 5‐compound formula validated in proof‐of‐experiments to extend lifespan and healthspan in human cells and C. elegans.
JiaYu Liu   +27 more
wiley   +1 more source

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

open access: yesAging Cell, EarlyView.
hAMSC‐sEVs rejuvenate β cells and improve glycaemic control via the miR‐21‐5p/IL‐6RA/STAT3/MCU axis, restoring mitochondrial Ca2+ homeostasis and insulin secretion in aged T2DM mice. ABSTRACT Targeting senescent pancreatic β‐cells represents a promising therapeutic avenue for age‐related diabetes; however, current anti‐senescence strategies often ...
Lei Xiao   +8 more
wiley   +1 more source

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