Results 61 to 70 of about 1,896 (253)

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Dynamic Interfacial pH Stabilization and (002) Oriented Deposition Enabled by Histidine‐Induced Solid Electrolyte Interphase for Highly Reversible Zn Anodes

Advanced Science, EarlyView.
The histidine‐induced ultrathin SEI (Zn(OH)2‐HIS) delivers exceptional anode stability by stabilizing the interfacial pH via a synergistic mechanism of chemical buffering and physical blocking, while inducing dendrite‐free oriented (002) deposition.
Qi Liu, Yimin Chen, Jianwei Lu, Xiangqun Zhuge, Xiyuan Zhong, Huaichong Sun, Yibing Li, Zhihong Luo, Kun Luo, Weiwei Lei, Dan Liu, Anjun Hu, Aijing Ma   +12 more
wiley   +1 more source

Jamcloud: Turning Traffic Jams Into Computation Opportunities–Whose Time Has Come

IEEE Access, 2019
Traffic jam has been and will remain a major problem in most cities around the world. We view this situation as a computation opportunity and propose to build the cloud-computing facilities on the top of jammed cars and other vehicles to turn the energy ...
Xuefeng Xiao, Xueshi Hou, Chuanmeizhi Wang, Yong Li, Pan Hui, Sheng Chen   +5 more
doaj   +1 more source

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Efficient Collaborative Edge Computing for Vehicular Network Using Clustering Service

Network
Internet of Vehicles applications are known to be critical and time-sensitive. The value proposition of edge computing comprises its lower latency, advantageous bandwidth consumption, privacy, management, efficiency of treatments, and mobility, which aim
Ali Al-Allawee, Pascal Lorenz, Alhamza Munther   +2 more
doaj   +1 more source

Emerging Memory and Device Technologies for Hardware‐Accelerated Model Training and Inference

Advanced Electronic Materials, EarlyView.
This review investigates the suitability of various emerging memory technologies as compute‐in‐memory hardware for artificial intelligence (AI) applications. Distinct requirements for training‐ and inference‐centric computing are discussed, spanning device physics, materials, and system integration.
Yoonho Cho, Dae‐won Kim, Yujin Kim, Jung‐Heum Na, Yuwon Jeong, Dong‐Yeop Lee, Shinhyun Choi   +6 more
wiley   +1 more source

Comparative Insights and Overlooked Factors of Interphase Chemistry in Alkali Metal‐Ion Batteries

Advanced Energy Materials, EarlyView.
This review presents a comparative analysis of Li‐, Na‐, and K‐ion batteries, focusing on the critical role of electrode–electrolyte interphases. It especially highlights overlooked aspects such as SEI/CEI misconceptions, binder effects, and self‐discharge relevance, emphasizing the limitations of current understanding and offering strategies for ...
Changhee Lee, Zachary T. Gossage, Shinichi Kumakura, Shinichi Komaba   +3 more
wiley   +1 more source

Game Theory Based Opportunistic Computation Offloading in Cloud-Enabled IoV

IEEE Access, 2019
With the growing popularity of the fifth-generation (5G) wireless systems and cloud-enabled Internet of Vehicles, vehicular cloud has been introduced as a novel mobile device computing mode, which enables vehicles to offload their computation-intensive ...
Minghui Liwang, Jiexiang Wang, Zhibin Gao, Xiaojiang Du, Mohsen Guizani   +4 more
doaj   +1 more source

Breaking the Polarity–Coordination Coupling in Electrolyte Design for High‐Voltage Lithium Batteries

Advanced Energy Materials, EarlyView.
Steric and electronic co‐regulation of 2,2,2‐trifluoro‐N, N‐dimethylethylamide (DMTFA) decouples high polarity from strong Li+ coordination, creating an anion‐mediated pseudo‐weakly solvating electrolyte. This design lowers Li+ desolvation barriers, enhances Li+ mobility, and builds B‐, F‐, and N‐rich inorganic interphases, enabling stable 3.0–4.6 V ...
Xue Li, Shangquan Zhao, Yifan Wu, Naigen Zhou, Fei Luo, Runze Liu, Chengjin Peng, Junzhi Li, Stefano Passerini, Shan Fang   +9 more
wiley   +1 more source