Results 231 to 240 of about 1,080,917 (315)

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Enteroscopic hemostasis for bleeding hepatopetal collaterals around a hepaticojejunostomy. [PDF]

Endoscopy
Soga K, Otani S, Takagi O, Yamaguchi M, Kuwada M, Kobori I, Sugimoto K.   +6 more
europepmc   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Apparent bilateral aldosterone suppression during adrenal venous sampling associated with preferential drainage into the left inferior phrenic vein. [PDF]

Endocrinol Diabetes Metab Case Rep
Nishigaki T, Yamamoto M, Higuchi Y, Yoshino K, Bando H, Matsushiro K, Gentsu T, Sofue K, Kanzawa M, Ogawa W, Fukuoka H.   +10 more
europepmc   +1 more source

Varicose Veins [PDF]

BMJ, 1940
openaire   +2 more sources

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

The Effectiveness and Security of the Tapered 4-Bladed Valvulotome (TF VenoCure2: VC) Used in Non-Reversed Translocated Saphenous Vein Bypass Surgeries. [PDF]

Ann Vasc Dis
Furuya T, Nagai M, Akai T, Nishimura T.
europepmc   +1 more source