Results 41 to 50 of about 54,131 (295)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Automatic Single Droplet Generator with Control over Droplet Size and Detachment Frequency

Colloids and Interfaces, 2019
This paper presents a quite simple, fully automatized single droplet generator, which can be an alternative for more expensive and complicated microfluidic devices. The simple generation nozzle connected to the pressure cells and cheap peristaltic pumps,
Dorota Gawel, Jan Zawala
doaj   +1 more source

Velocity Dispersion of Excited H2

, 2005
We present a study of the high rotational bands (J > 2) of H2 toward 4 early type galactic stars: HD 73882, HD 192639, HD 206267, and HD 207538. In each case, the velocity dispersion - characterized by the spectrum fitting parameter b - increases with the level of excitation, a phenomenon that has previously been detected by the Copernicus and IMAPS
Lacour, S., Ziskin, V., Hebrard, G., Oliveira, C., Andre, M. K., Ferlet, R., Vidal-Madjar, A.   +6 more
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Group-velocity-dispersion engineering of tantala integrated photonics

Optics Letters, 2021
Designing integrated photonics, especially to leverage Kerr-nonlinear optics, requires accurate and precise knowledge of the refractive index across the visible to infrared spectral ranges. Tantala ( T a 2 O 5 ) is an ...
Jennifer A. Black, Richelle Streater, Kieran F. Lamee, David R. Carlson, Su-Peng Yu, Scott B. Papp   +5 more
openaire   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

On the Origin of the Variety of Velocity Dispersion Profiles of Galaxies

The Astrophysical Journal
Observed and simulated galaxies exhibit a significant variation in their velocity dispersion profiles. We examine the inner and outer slopes of stellar velocity dispersion profiles using integral field spectroscopy data from two surveys, SAMI (for z < 0 ...
San Han, Sukyoung K. Yi, Sree Oh, Mina Pak, Scott Croom, Julien Devriendt, Yohan Dubois, Taysun Kimm, Katarina Kraljic, Christophe Pichon, Marta Volonteri   +10 more
doaj   +1 more source

The velocity dispersion among galaxies

The Astrophysical Journal, 1981
The galaxies in the Revised Shapley-Ames redshift catalog, which is complete to Broughly-equal13, are used to determine the velocity dispersion in the local galaxy field (..nu..
A. R. Rivolo, A. Yahil
openaire   +1 more source