Results 51 to 60 of about 54,131 (295)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The SAMI Galaxy Survey: the difference between ionized gas and stellar velocity dispersions [PDF]

, 2022
Sree Oh, Matthew Colless, Francesco D’Eugenio, S. M. Croom, L. Cortese, Brent Groves, Lisa J. Kewley, Jesse van de Sande, Henry R. M. Zovaro, Mathew Varidel, Stefania Barsanti, Joss Bland‐Hawthorn, Sarah Brough, Julia J. Bryant, Sarah Casura, Jon Lawrence, Nuria P. F. Lorente, Anne M. Medling, M. S. Owers, Sukyoung K. Yi   +19 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Determination and impact factor analysis of hydrodynamic dispersion coefficient within a gravel layer using an electrolyte tracer method

International Soil and Water Conservation Research, 2016
Hydrodynamic dispersion is a measure for describing the process of solute transport in porous media. Characterizing the dispersion of water flow within gravel is essential for the prediction of solute transport especially nonpoint source pollutants ...
Xiaonan Shi, Tingwu Lei, Yan Yan, Fan Zhang   +3 more
doaj   +1 more source

Velocity dispersion and dynamical mass for 270 galaxy clusters in thePlanckPSZ1 catalogue [PDF]

, 2021
A. Ferragamo, R. Barrena, J. A. Rubiño-Martín, A. Aguado-Barahona, A. Streblyanska, D. Tramonte, R. Génova-Santos, A. Hempel, H. Lietzen   +8 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Gaussian Process Methods for Very Large Astrometric Data Sets

The Astrophysical Journal
We present a novel nonparametric method for inferring smooth models of the mean velocity field and velocity dispersion tensor of the Milky Way from astrometric data.
Timothy Hapitas, Lawrence M. Widrow, Thavisha E. Dharmawardena, Daniel Foreman-Mackey   +3 more
doaj   +1 more source

Velocity dispersions in statistical lensing

The Astrophysical Journal, 1993
The theoretical average line-of-sight velocity dispersion along the radius of a spherical galaxy or cluster of galaxies tends to a variable value. Statistical lensing studies often take into account only the asymptotic value, either close to the center or at large distances, rather than the full variation: this results in significant effects in lensing
openaire   +1 more source