Results 61 to 70 of about 2,224,936 (294)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

IN-SYNC. II. VIRIAL STARS FROM SUBVIRIAL CORES—THE VELOCITY DISPERSION OF EMBEDDED PRE-MAIN-SEQUENCE STARS IN NGC 1333 [PDF]

, 2014
The initial velocity dispersion of newborn stars is a major unconstrained aspect of star formation theory. Using near-infrared spectra obtained with the APOGEE spectrograph, we show that the velocity dispersion of young (1–2 Myr) stars in NGC 1333 is 0 ...
J. Foster, M. Cottaar, K. Covey, H. Arce, M. Meyer, D. Nidever, K. Stassun, J. Tan, S. Chojnowski, N. da Rio, K. Flaherty, L. Rebull, P. Frinchaboy, S. Majewski, M. Skrutskie, John C. Wilson, G. Zasowski   +16 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Effects of inclination on measuring velocity dispersion and implications for black holes [PDF]

, 2014
The relation of central black hole mass and stellar spheroid velocity dispersion (the M-$\sigma$ relation) is one of the best-known and tightest correlations linking black holes and their host galaxies.
J. Bellovary, K. Holley-Bockelmann, K. Gultekin, C. Christensen, F. Governato, A. Brooks, S. Loebman, F. Munshi   +7 more
semanticscholar   +1 more source

Velocity Dispersions of Quiescent Galaxies in IllustrisTNG

The Astrophysical Journal
We examine the central stellar velocity dispersion of subhalos based on IllustrisTNG cosmological hydrodynamic simulations. The central velocity dispersion is a fundamental observable that links galaxies with their dark matter subhalos.
Jubee Sohn, Margaret J. Geller, Josh Borrow, Mark Vogelsberger   +3 more
doaj   +1 more source

Automatic Single Droplet Generator with Control over Droplet Size and Detachment Frequency

Colloids and Interfaces, 2019
This paper presents a quite simple, fully automatized single droplet generator, which can be an alternative for more expensive and complicated microfluidic devices. The simple generation nozzle connected to the pressure cells and cheap peristaltic pumps,
Dorota Gawel, Jan Zawala
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Strong group-velocity dispersion compensation with phase-engineered sheet metamaterials [PDF]

, 2014
Resonant metamaterials usually exhibit substantial dispersion, which is considered a shortcoming for many applications. Here we take advantage of the ability to tailor the dispersive response of a metamaterial, introducing a new method of group-velocity ...
B. Dastmalchi, P. Tassin, T. Koschny, C. Soukoulis   +3 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The relation between velocity dispersion and mass in simulated clusters of galaxies: dependence on the tracer and the baryonic physics [PDF]

, 2013
[Abridged] We present an analysis of the relation between the masses of cluster- and group-sized halos, extracted from $\Lambda$CDM cosmological N-body and hydrodynamic simulations, and their velocity dispersions, at different redshifts from $z=2$ to $z ...
E. Munari, A. Biviano, S. Borgani, G. Murante, D. Fabjan   +4 more
semanticscholar   +1 more source