Results 51 to 60 of about 289,177 (314)

A New Identification Method of Underground Excavation Based on Velocity Estimation Using Double Point Synchronous Measurements

open access: yesIEEE Access, 2020
In an assault on a military fortress, the attacking side often attacks the fortress through the use of underground mining, so that the defensive side cannot be prepared.
Dongze Qin, Jinshi Zhang
doaj   +1 more source

Extraction of accurate cytoskeletal actin velocity distributions from noisy measurements

open access: yesNature Communications, 2022
Dynamic remodeling of the actin cytoskeleton underlies cell movement, but is challenging to characterize at the molecular level. Here, the authors present a method to extract actin filament velocities in living cells, and compare their results to current
Cayla M. Miller   +2 more
doaj   +1 more source

FIELD MEASUREMENTS OF NEARSHORE VELOCITIES

open access: yesCoastal Engineering Proceedings, 1974
Two component electromagnetic flowmeters are being used as the basis of an apparatus to measure nearshore velocities on natural beaches. The flowmeters are mounted on free standing tripods, 1 m. base side and 0.3 m. high, to measure the two components of horizontal flow, and have been used in depths of up to 4 m. and up to 150 m.
David A. Huntley, Anthony J. Bowen
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Measurements of Shear Wave Velocity for Collapsible Soil

open access: yesGeotechnics
This paper examines the effects of collapsible soil structure on shear wave velocity. The study attempts to simulate hydraulic fill sand deposits, which represent a natural soil deposition process that can result in a collapsible soil structure. A series
Omar EI-Shafee   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

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