Results 261 to 270 of about 122,299 (311)

Mortality in Tuberous Sclerosis Complex in the United Kingdom, 2016–2022

open access: yesJournal of Intellectual Disability Research, Volume 69, Issue 6, Page 457-464, June 2025.
ABSTRACT Background Tuberous sclerosis complex (TSC) is a genetic condition caused by mutations in either TSC1 or TSC2 genes, affecting around two million people globally. This study aims to examine causes of death in TSC and explore factors contributing to mortality in people with TSC in the United Kingdom in recent years following updated management ...
Callum Richard Thomas Kidson   +2 more
wiley   +1 more source

Duodenal-caval fistula from eroding inferior vena cava stent requiring explant and duodenal repair. [PDF]

open access: yesJ Vasc Surg Cases Innov Tech
Wang KM   +3 more
europepmc   +1 more source

Surrogate Markers of Intestinal Permeability, Bacterial Translocation and Gut–Vascular Barrier Damage Across Stages of Cirrhosis

open access: yesLiver International, Volume 45, Issue 6, June 2025.
ABSTRACT Background and Aims Portal hypertension, gut barrier dysfunction, and pathological bacterial translocation are hallmarks of cirrhosis driving complications. As measuring gut barrier function is demanding, surrogate markers have been proposed, but their intercorrelation and applicability across different stages of advanced liver disease ...
Frederic Haedge   +9 more
wiley   +1 more source

Off label use of a 7Fr endo-biliary forceps system for endovascular inferior vena cava biopsy. [PDF]

open access: yesCVIR Endovasc
Grigoriadis S   +5 more
europepmc   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

open access: yesAdvanced Science, Volume 12, Issue 18, May 15, 2025.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma   +13 more
wiley   +1 more source

Alterations to peritubular capillary structure in a rat model of kidney interstitial fibrosis: Implications for oxygen diffusion

open access: yesThe Anatomical Record, Volume 308, Issue 5, Page 1492-1503, May 2025.
Abstract Fibrosis and loss of functional capillary surface area may contribute to renal tissue hypoxia in a range of kidney diseases. However, there is limited quantitative information on the impact of kidney disease on the barriers to oxygen diffusion from cortical peritubular capillaries (PTCs) to kidney epithelial tubules.
Sarah E. Gazzard   +9 more
wiley   +1 more source

Preclinical Pharmacokinetic Assessment of a Promising Vasorelaxant, Analgesic, and Anti‐Inflammatory Prototype 5‐[1‐(4‐Fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole (LQFM020) Through Selective Bioanalytical HPLC‐PDA‐Based Method

open access: yesBiomedical Chromatography, Volume 39, Issue 5, May 2025.
ABSTRACT A simple and selective high‐performance liquid chromatography bioanalytical method was developed and validated to determine the pharmacokinetic parameters of 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole (LQFM020) with promising vasorelaxant, anti‐inflammatory, and antinociceptive properties while verifying its potential hepatic enzyme ...
Lanussy Porfiro de Oliveira   +10 more
wiley   +1 more source

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