Results 151 to 160 of about 52,622 (253)

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, Volume 183, Issue 17, Page 5315-5335, September 2026.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

Feasibility and Safety of Median Sternotomy Combined With Hemi‐Clamshell Incisions for the Resection of Extremely Large Tumors in the Thoracic Cavity: A Case Series

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT To evaluate the feasibility and safety of median sternotomy combined with hemi‐clamshell thoracotomy for resection of extremely large intrathoracic tumors. The perioperative data of three patients with large tumors in the thoracic cavity from January 2021 to December 2024 were collected and analyzed retrospectively, and median sternotomy ...
Xiaoyun Li, Mei Xu, Mingyu Fan, Xiaojun Tang   +3 more
wiley   +1 more source

Unique One‐Stage Procedure: Simultaneous Patent Foramen Ovale Closure and Resection of Wilms Tumor With Vena Cava Thrombus in a 5‐Year‐Old

Clinical Case Reports, Volume 14, Issue 8, August 2026.
Combined cardiac and abdominal surgery in a child with nephroblastoma, inferior vena cava tumor thrombus extending to the right atrium, and patent foramen ovale. ABSTRACT Wilms tumor with intravascular extension poses significant surgical challenges, particularly when combined with a patent foramen ovale, which adds the risk of paradoxical embolism. We
Lea‐Kathrin Hammer, Tsvetomir Loukanov, Patrick Günther, Mina Farag, Angela‐Maria Czundel, Berthold Klein, Markus Kessler, Christoph W. Michalski, Juri Fuchs   +8 more
wiley   +1 more source

A rare case of non-obstructed total anomalous pulmonary venous connection with a giant superior vena cava aneurysm complicated by acute young ischemic stroke. [PDF]

BMC Cardiovasc Disord
Jiang W, Liu W, Zhao H, Yu Q, Zhang F.
europepmc   +1 more source

Successful Repositioning of a Tunneled Cuffed Catheter Misplaced Into the Ascending Lumbar Vein

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT A tunneled cuffed catheter was misplaced into the ascending lumbar vein. Fortunately, the catheter tip was withdrawn and successfully repositioned into the inferior vena cava under fluoroscopy.
Xiaohe Wang, Qianqian Jin, Jia Zhi
wiley   +1 more source

Simultaneous Heart–Kidney Transplantation for Ebstein's Anomaly: A Viable Treatment Option in Latin America

Clinical Case Reports, Volume 14, Issue 8, August 2026.
Chest x‐ray showing a typical presentation of Ebstein anomaly with severe cardiomegaly and a prominent right atrium silhouette. ABSTRACT Simultaneous heart–kidney transplantation is a viable and effective treatment option for patients with congenital heart disease and advanced chronic kidney disease when both conditions threaten survival.
Edgar García‐Cruz, Andrea Luna‐Hernández, Jesús Alberto Blanco‐Hernández, Jorge Sánchez‐Nieto, Stephanie Teresa Angulo‐Cruzado, Karla Alejandra Pupiales‐Dávila, Carla Domínguez‐Pereyra, Reyna Moreno‐Ruíz, Carlos Antonio Villegas‐Chávez, Antonio Jordán‐Ríos, Daniel Manzur‐Sandoval, Victor Alejandro Quiroz‐Martínez, Francisco Martín Baranda‐Tovar   +12 more
wiley   +1 more source

A Closed‐Loop Cardiovascular Model of the Supine‐To‐Stand Manoeuvre: Implications for Falls

International Journal for Numerical Methods in Biomedical Engineering, Volume 42, Issue 8, August 2026.
Continuous beat‐to‐beat modeling of supine‐to‐stand hemodynamics in older adults reproduces orthostatic responses and reveals differences in baroreflex, muscle‐pressure, and blood volume in those with a fall history, providing a basis for mechanistic phenotyping to enhance orthostatic hypotension diagnosis.
Joeri A. van de Sande, Valeria Krzhizhanovskaya, Lex M. van Loon, Nathalie van der Velde, Eveline P. van Poelgeest, Marjolein Klop, Jurgen A. H. R. Claassen, Alfons G. Hoekstra   +7 more
wiley   +1 more source

Case Report: Analysis of the missed diagnosis of atrial septal defect with partial pulmonary vein dual drainage. [PDF]

Front Cardiovasc Med
Zhou CH, Zhang YY, Shen QS.
europepmc   +1 more source

Development and External Validation of an Efficient Deep Learning Model for Lesion Segmentation and Subtyping of Hepatic Echinococcosis in Ultrasound Imaging

Health Care Science, Volume 5, Issue 4, Page 284-298, August 2026.
We developed a lightweight deep learning framework that integrates frequency‐ and spatial‐domain ultrasound features with segmentation‐assisted classification for hepatic echinococcosis diagnosis. The model outperformed existing state‐of‐the‐art methods in both accuracy and inference speed while requiring substantially fewer computational resources ...
Zhu He, Jiajun Qiu, Chenlin Du, Jin Yin, Xuhui Zhang, Yelei Ren, Yifei Wang, Lamu Suolang, Chunyang Li, Zongjiu Zhang, Diming Cai, Qicheng Lao   +11 more
wiley   +1 more source

Anomalous Coronary Venous Drainage to the Right Atrium: A Case Report. [PDF]

Cureus
Luna E, Aher A, Reddy R, Luna C, Aher P.
europepmc   +1 more source