Results 41 to 50 of about 4,351 (98)

The Effectiveness and Safety Profile of Nivolumab‐Plus‐Ipilimumab in Previously Untreated Japanese Patients With Advanced or Metastatic Renal Cell Carcinoma (J‐ENCORE Study)

International Journal of Urology, EarlyView.
ABSTRACT Objectives Combination therapy of nivolumab‐plus‐ipilimumab has been approved for advanced or metastatic renal cell carcinoma in Japan, but large‐scale clinical data targeting Japanese patients is limited. To evaluate the early outcomes and factors related to early progression and response.
Koshiro Nishimoto, Go Kimura, Tomokazu Sazuka, Shuzo Hamamoto, Masahiro Nozawa, Kazuyuki Numakura, Atsushi Mizokami, Tsunenori Kondo, Sei Naito, Takashige Abe, Kojiro Ohba, Masayoshi Nagata, Shunta Onodera, Hiroaki Ito, Hirotsugu Uemura   +14 more
wiley   +1 more source

Comparison of Modified Oblique Lateral Interbody Fusion and Posterior‐Only Approach in the Treatment of Degenerative Lumbar Scoliosis

Orthopaedic Surgery, EarlyView.
Comparison of Modified Oblique Lateral Interbody Fusion and Posterior‐Only Approach in the Treatment of Degenerative Lumbar Scoliosis. ABSTRACT Objective Degenerative lumbar scoliosis (DLS) often requires surgical intervention, but traditional posterior‐only approaches, despite their effectiveness, result in significant muscle damage and high ...
Xiang Zhang, Yongqiang Wang, Yilin Lu, Junyu Li, Zhuoran Sun, Yan Zeng, Weishi Li, Miao Yu   +7 more
wiley   +1 more source

Comparison of a New Minimally Invasive Reduction Technique Using Open Wiring in the Treatment of Subtrochanteric Femur Fractures

Orthopaedic Surgery, EarlyView.
(a and b) Typical external, abduction, and flexion deformity of the proximal fragment occurred after longitudinal traction. (c and d) Reduction was satisfactory after inserting four long hemostatic forceps. How to overcome proximal femoral deformities after longitudinal traction challenges most of the surgeons.
Teng Ma, Chaofeng Wang, Qiang Huang, Hua Lin, Qian Wang, Cheng Ren, Yibo Xu, Kun Zhang, Congming Zhang, Deyin Liu   +9 more
wiley   +1 more source

An experimentally informed computational model of neurovestibular adaptation to altered gravity

Experimental Physiology, EarlyView.
Abstract Transitions to altered gravity environments result in acute sensorimotor impairment for astronauts, leading to serious mission and safety risks in the crucial first moments in a new setting. Our understanding of the time course and severity of impairment in the early stages of adaptation remains limited and confounded by unmonitored head ...
Victoria G. Kravets, Torin K. Clark
wiley   +1 more source

Nutrigenomic insights and cardiovascular benefits of blackberry (Rubus ulmifolius Schott.) and mugwort (Artemisia campestris L.)

Experimental Physiology, EarlyView.
Abstract Blackberry (Rubus ulmifolius Schott) and mugwort (Artemisia campestris L.) are plants traditionally used to treat various pathologies, including hypertension. The vasodilatory and hypotensive effects of blackberry were investigated through experiments in rat models (n = 5 rats per group) and compared with those of mugwort, which had been ...
Afaf Mehiou, Anca Lucau‐Danila, Zachee L. E. Akissi, Chaimae Alla, Nourelhouda Bouanani, Abdelkhaleq Legssyer, Jean‐Louis Hilbert, Sevser Sahpaz, Abderrahim Ziyyat   +8 more
wiley   +1 more source

How Do Individually Ventilated Cages Affect the Welfare of Male BALB/c Mice? Comprehensive Assessment of Behavior, Metabolism, and Responses to Acute Painful Stimuli

Brain and Behavior, Volume 15, Issue 6, June 2025.
IVC housing conditions cause significant changes in behavioral patterns, metabolism, and nociceptive responses in mice. ABSTRACT Introduction Housing conditions, which have a major impact on the welfare of laboratory animals, are an important issue in experimental research.
Aslı Çelik, Cemre Ural, Hatice Efsun Kolatan, Pembe Keskinoğlu, Mehmet Ateş, Zahide Çavdar, Osman Yılmaz, Mehmet Ensari Güneli   +7 more
wiley   +1 more source

In heart failure, echocardiographic parameters of right ventricular function are powerful tools to predict renal failure

ESC Heart Failure, Volume 12, Issue 3, Page 2310-2320, June 2025.
Abstract Background Chronic kidney disease (CKD) has a high prevalence in patients with heart failure (HF) and is associated with prolonged hospitalization, increased need for intensive care and mortality. There is an urgent need to identify factors that influence the interaction between heart and kidney disorders, often described as cardiorenal ...
Alexander Reinecke, Paulina Dißmann, Norbert Frey, Oliver J. Müller, Hatim Seoudy, Johanne Frank, Derk Frank, Martina E. Spehlmann   +7 more
wiley   +1 more source

Long‐term outcomes of apixaban as main anticoagulant in patients with HeartMate 3 left ventricular assist devices

ESC Heart Failure, Volume 12, Issue 3, Page 1714-1718, June 2025.
Abstract Aims HeartMate 3 (HM3) left ventricular assist devices (LVADs) offer improved haemocompatibility‐related outcomes for end‐stage heart failure patients, facilitating the exploration of alternative anticoagulation therapies beyond warfarin.
Jennifer Jdaidani, Mahmoud Shadi, Nnedi Asogwa, Jennifer Winik, Dora Rossi, Christina Saikus, Maria D. Avila, Geurys R. Rojas‐Marte   +7 more
wiley   +1 more source

Predicting right ventricular failure after left ventricular assist device implant: A novel approach

ESC Heart Failure, Volume 12, Issue 3, Page 1916-1931, June 2025.
Abstract Aims Right ventricular (RV) failure (RVF) after left ventricular assist device (LVAD) implant is an important cause of morbidity and mortality. Modern, data‐driven approaches for defining and predicting RVF have been under‐utilized. Methods Two hundred thirty‐two patients were identified with a mean age of 55 years; 40 (17%) were women, 132 ...
Carissa E. Livingston, Dale Kim, Lacey Serletti, Andrea Jin, Sriram Rao, Michael V. Genuardi, Eliot G. Peyster   +6 more
wiley   +1 more source

Randomized trial to assess worsening renal function by adding dapagliflozin for acute decompensated heart failure

ESC Heart Failure, Volume 12, Issue 3, Page 2023-2033, June 2025.
Abstract Aims Dapagliflozin (DAPA), a sodium‐glucose co‐transporter 2 inhibitor, has been shown to reduce cardiovascular mortality among patients with chronic heart failure. We aimed to evaluate the impact on a worsening renal function (WRF) by adding DAPA as compared to standard decongestive therapy with loop diuretics alone.
Shodai Kawanami, Yasuyuki Egami, Masaru Abe, Mizuki Osuga, Hiroaki Nohara, Kohei Ukita, Akito Kawamura, Koji Yasumoto, Naotaka Okamoto, Yasuharu Matsunaga‐Lee, Masamichi Yano, Masami Nishino   +11 more
wiley   +1 more source