Results 221 to 230 of about 129,700 (299)

Proteomic Trajectories of Metabolic and Proteostatic Adaptation During Normothermic Liver Perfusion

open access: yesLiver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background Normothermic machine perfusion (NMP) enables metabolic restoration and viability testing of liver grafts, but current viability criteria incompletely predict post‐transplant outcomes. The molecular basis of graft resilience or biliary vulnerability remains unclear. This study aimed to characterise tissue‐level proteomic trajectories
Heithem Jeddou   +10 more
wiley   +1 more source

Pacemaking in the heart: a redundant and robust system of mutually entrained oscillators driving cardiac automaticity

open access: yesThe Journal of Physiology, Volume 604, Issue 9, Page 3504-3512, 1 May 2026.
Abstract figure legend Cardiac pacemaking: the redundant and robust organ‐to‐subcellular system driving the spontaneous electrical activity responsible for regular, rhythmic excitation of the heart. Abstract The heart is an electrically controlled, mechanical pump that provides a constant supply of blood to the body.
Eilidh A. MacDonald, T. Alexander Quinn
wiley   +1 more source

Purification and Transcriptomic Characterization of Hypertrophied Hepatic Stellate Cells From CDAHFD Mouse Liver

open access: yesThe FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The purification protocol for hypertrophied hepatic stellate cells (hypHSCs) developed in this study, using fibrotic and steatotic mouse livers (CDAHFD model), made it possible to obtain a high‐purity hypHSC preparation for transcriptomic analysis.
Marion Heckmann   +9 more
wiley   +1 more source

Aberrant DNMTs Promote TXNIP Upregulation and Ovarian Fibrosis in PCOS

open access: yesThe FASEB Journal, Volume 40, Issue 7, 15 April 2026.
In a rat model of DHEA/DHT‐induced PCOS and in granulosa cells (GCs), upregulated DNMT1, DNMT3A, and DNMT3B inhibit TXNIP degradation, leading to TXNIP accumulation, which drives ovarian fibrosis and tissue injury. ABSTRACT Hyperandrogenism and elevated thioredoxin‐interacting protein (TXNIP) are potential causes of infertility in women with polycystic
Yajing Weng   +12 more
wiley   +1 more source

Lymphocyte Antigen 6G Mediates Vagotomy‐Associated Reduction in Body Weight

open access: yesThe FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Vagotomy was associated with lower body weight and epididymal white adipose tissue (eWAT) mass, as well as increased Ly6G+ cell infiltration in eWAT. This vagotomy‐associated weight loss was significantly attenuated in neutrophil‐deficient mice, suggesting Ly6G+ cells participate in the regulation of eWAT energy homeostasis.
Ting Liu   +18 more
wiley   +1 more source

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