Results 51 to 60 of about 378,557 (253)

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok   +13 more
wiley   +1 more source

Taxed Congestion Games with Failures

open access: yes, 2009
In this paper, we introduce and study Taxed Congestion Games with Failures [TCGFs], extending congestion games with failures [CGFs] to consider costly task submission. We define TCGFs, and prove that TCGFs possess a pure strategy equilibrium.
Polukarov, Maria   +2 more
core   +1 more source

Design and analysis for TCP-friendly window-based congestion control [PDF]

open access: yes, 2006
The current congestion control mechanisms for the Internet date back to the early 1980’s and were primarily designed to stop congestion collapse with the typical traffic of that era.
Choi, S.-H., Soo-hyun Choi
core  

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao   +8 more
wiley   +1 more source

Assessment of Congestion in Heart Failure Using VExUS: Current Evidence, Limitations and Clinical Perspectives

open access: yesLife
Background: Systemic venous congestion is a key driver of organ dysfunction in heart failure (HF), yet accurate non-invasive quantification remains challenging. Recognizing residual congestion is critical, since it predicts HF readmissions and mortality.
Cosmina-Georgiana Ponor   +8 more
doaj   +1 more source

Pathomechanisms in central serous chorioretinopathy: A recent update

open access: yesInternational Journal of Retina and Vitreous, 2023
Background Central serous chorioretinopathy (CSCR) is a potentially blinding choroidal disease. Despite decades of research, the pathological mechanisms of CSCR are still poorly understood.
Arman Zarnegar   +4 more
doaj   +1 more source

Transport congestion events detection (TCED): towards decorrelating congestion detection from TCP [PDF]

open access: yes, 2010
TCP (Transmission Control Protocol) uses a loss-based algorithm to estimate whether the network is congested or not. The main difficulty for this algorithm is to distinguish spurious from real network congestion events.
Anelli, Pascal   +4 more
core  

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

open access: yesAdvanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan   +14 more
wiley   +1 more source

Role of venous excess ultrasound (VExUS) protocol in grading systemic venous congestion in adult Egyptian patients with congestive heart failure: a prospective study

open access: yesThe Egyptian Journal of Radiology and Nuclear Medicine
Background Heart failure (HF) is a prevalent condition associated with substantial morbidity and mortality globally. Persistent congestion, particularly systemic venous congestion, can precipitate organ dysfunction and is linked to adverse clinical ...
Christina M.Kamil   +5 more
doaj   +1 more source

The use of venous Doppler to predict adverse kidney events in a general ICU cohort

open access: yesCritical Care, 2020
Background Changes in Doppler flow patterns of hepatic veins (HV), portal vein (PV) and intra-renal veins (RV) reflect right atrial pressure and venous congestion; the feasibility of obtaining these assessments and the clinical relevance of the findings ...
Rory Spiegel   +9 more
doaj   +1 more source

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