Results 231 to 240 of about 101,068 (248)

AZD0449, an inhaled JAK1 inhibitor, in healthy participants and patients with mild asthma

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 257-268, January 2026.
Aims Inhaled corticosteroids (ICS) plus bronchodilator are recommended for the treatment of asthma. Targeting the JAK1‐dependent pathway may be an alternative for asthma management in patients with incomplete response to ICS. The aim of this study was to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD0449, a
Anna Lundahl   +11 more
wiley   +1 more source

An international survey of clinician recommendations for physical activity after venous thromboembolism. [PDF]

open access: yesThromb Res
Chan A   +12 more
europepmc   +1 more source

Neck‐vein thrombosis during spaceflight

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 24-34, January 2026.
Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck‐vein thrombosis, a condition rarely seen on Earth without predisposing factors such as venous catheters or infections.
Ulrich Limper, Jens Jordan
wiley   +1 more source

Unravelling the role of TET2 in venous thromboembolism: insights into mechanisms and therapeutic implications. [PDF]

open access: yesFront Cardiovasc Med
Bai Y   +9 more
europepmc   +1 more source

Immune‐Mediated Thrombocytopenia in an Ulcerative Colitis Patient After Initiating Filgotinib Treatment: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 1, January 2026.
Timeline of events ABSTRACT Moderate‐to‐severe ulcerative colitis can be effectively treated with JAK‐1 inhibition, but platelet counts should be closely monitored, especially in active disease. We confirmed immune‐mediated thrombocytopenia (ITP) in one of our patients after the initiation of filgotinib. Whether this was drug‐induced is uncertain.
M. J. van der Hoff   +2 more
wiley   +1 more source

Multi‐Chamber Intracardiac Thrombi Complicated With Pulmonary and Lower Extremity Thrombosis in Male Patient: Case Report and Literature Reviews

open access: yesClinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Multi‐chamber intracardiac thrombi are a rare and high‐risk complication in dilated cardiomyopathy, even during sinus rhythm. This case highlights the associated dangers of hemodynamic compromise and systemic embolization. Management requires vigilant anticoagulation and close monitoring to balance thromboembolic and bleeding risks.
Eba Fufa   +10 more
wiley   +1 more source

The Crucial Role of Tinzaparin in Managing Venous Thromboembolism in the Cancer Population. [PDF]

open access: yesJ Clin Med
Mauriello A   +8 more
europepmc   +1 more source

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