Results 31 to 40 of about 80,404 (289)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Macrofaunal ecology of sedimented hydrothermal vents in the Bransfield Strait, Antarctica
Frontiers in Marine Science, 2016 Sedimented hydrothermal vents, where hot, mineral-rich water flows through sediment, are poorly understood globally, both in their distribution and the ecology of individual vent fields.
James Benjamin Bell +7 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Effect of opening diffuser and return vent location on air quality, thermal comfort and energy saving in desk displacement ventilation (DDV) system [PDF]
Journal of Heat and Mass Transfer Research, 2018 Recently, many investigations have been performed on return vent height; showing that the height of 1.3 m from the floor is the best height for this vent.
Amir Mohammad Jadidi +2 more
doaj +1 more source
Modification of togok (tidal trap) for reducing bycatch by using BRD vent
Depik Jurnal, 2022 One effort to reduce bycatch in togok is to modify the togok by creating a vent to reduce bycatch by BRD. The BRD installed on the togok was a rope BRD vent made of Polyethelene (PE) with a diameter of 2 mm.
Nofrizal Nofrizal +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Frontiers in Marine Science, 2022 Hydrothermal vents have been recognised as isolated islands of productivity in the deep sea, but very little is known about the transport and export of chemoautotrophic produced organic carbon to vent surrounding habitats.
Reyhaneh Roohi +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source