Results 41 to 50 of about 80,404 (289)

Dimensional Standards of Seima-Turbino Castings with Eyes

СибСкрипт
The article features the dimensions applied by ancient figure casters. It summarizes the findings of eye molding forms for spearheads and axe blades from the Ob-Irtysh interfluve.
Yu. I. Mikhailov
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Environmental and Hydrogeochemical Controls of Spicular Geyserite in Opaline Hot Spring Deposits

Earth and Space Science, 2023
Siliceous spicules are micro‐laminated geyserite deposits, or micro‐stromatolites, found around high temperature hot‐springs and geysers, associated with intermittent splashes of water.
C. Munoz‐Saez, J. Gong, A. Perez‐Fodich, M. A. vanZuilen   +3 more
doaj   +1 more source

New Record of Hydrothermal Vent Squat Lobster (Munidopsis lauensis) Provides Evidence of a Dispersal Corridor between the Pacific and Indian Oceans [PDF]

, 2022
Hee-seung Hwang, Boongho Cho, Jaemin Cho, Beomseok Park, Tae Won Kim   +4 more
openalex   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

L’effet de la géométrie urbaine sur l’écoulement du vent et la ventilation naturelle extérieure

Revue des Énergies Renouvelables, 2012
Le vent est l’un des facteurs qui déterminent le succès ou l’échec d’un espace public. Comme il représente un élément assez perceptible du microclimat urbain, il exerce une grande influence sur le confort thermique. Il peut être une source de ventilation
S. Bouketta, Y. Bouchahm
doaj  

Numerical Study on the Influence of Various Design Variables on the Behavior Characteristics of Oil and Gas in Internal Floating Roof Tanks

Energies
With the development of the petrochemical industry, the number of storage tanks has continuously increased, exacerbating the issue of oil evaporation losses.
Ji-Chao Li, Ming Liu, Shi-Wang Dang, Ling-Chong Hu, Guang Chen, Sheng-Dong Zhang, Xiang-Hu Kong, Heng Xu   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reproductive adaptations of the hydrothermal vent crab Xenograpus testudinatus: An isotopic approach.

PLoS ONE, 2019
The vent crab Xenograpsus testudinatus was firstly discovered in 2000 at the hydrothermal vent field off the coast of Kueishan Island. The present study attempts to understand the adaptive reproduction of this crab living in an extreme environment by ...
Jia-Jang Hung, Shao-Hung Peng, Chen-Tung Arthur Chen, Tsui-Ping Wei, Jiang-Shiou Hwang   +4 more
doaj   +1 more source