Results 221 to 230 of about 3,345,378 (306)

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet   +6 more
wiley   +1 more source

Maximal exercise at high altitude does not exacerbate inflammation in the human brain

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study investigated arterial–internal jugular venous (IJV) exchange of cytokines in response to low‐intensity and maximal cycling exercise at sea level and following 6–8 days at 3800 m a.s.l. There was a shift towards net release of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), monocyte chemoattractant protein‐1 (MCP‐1) and ...
Hannah G. Caldwell   +11 more
wiley   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu   +5 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

High‐throughput, high‐fidelity reconstruction of whole mouse‐heart cytoarchitecture at cellular scale

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Experimental workflow of the dual‐camera light‐sheet microscope (dual‐mesoSPIM) pipeline. Intact adult mouse hearts undergo CUBIC‐based delipidation and refractive‐index matching, rendering the whole organ optically transparent (left).
Francesco Giardini   +12 more
wiley   +1 more source

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