Results 181 to 190 of about 4,736,339 (290)

Predicting 12-month functional outcome in Guillain-Barré syndrome by combining acute-phase clinical data and traditional Chinese medicine syndrome features: a retrospective machine learning study. [PDF]

Front Neurol
Hu P, Liu J, Tang Y, Huang J, Chen X, Liu C, Wang Y.   +6 more
europepmc   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Research on the Prevention and Control of Blast Impact Pressure in Deep Holes and the Mechanism of Coordinated Extraction of Harmful Gases. [PDF]

ACS Omega
Men J, Xiong B, Wang Z, Ye Z, Li J, Lu D.   +5 more
europepmc   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Evolutionary patterns and research frontiers in ventilator-induced lung injury: a bibliometric analysis (2000-2024). [PDF]

J Thorac Dis
Wu Y, Pan L.
europepmc   +1 more source

From Responsibility to Resilience to Social Innovation: A Cyclical Theory of Responsible Networked Resilience in External Crises

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT External crises unsettle resources, routines, and what responsible action means. Prior research links CSR to stakeholder support and resilience. Yet these relationships remain fragmented, leaving mechanisms connecting responsibility, inter‐organizational cooperation, resilience, social innovation, and renewed responsibility expectations under ...
Darine Azzam
wiley   +1 more source

VQ-Wave: A Physics-Driven Spatiotemporal Deep Learning Approach for Noncontrast-Enhanced Lung Ventilation and Perfusion MRI. [PDF]

Magn Reson Med
Bauman G, Panos P, Latzin P, Bieri O.
europepmc   +1 more source

Fracture evolution of a thick soft protection layer and the water inrush mechanism in overburden under longwall mining

Deep Underground Science and Engineering, EarlyView.
Through shear–tensile creep tests and viscoelastic modeling, the fracture evolution of thick soft protective layers is clarified. Results show thickness‐dependent rheological failure modes that govern four types of roof water inrush, providing a mechanism‐based framework for hazard prediction and control. Abstract In the Jurassic coal‐bearing strata of
Mengnan Liu, Wei Qiao, Xianggang Cheng, Xiangsheng Meng, Peichao Feng   +4 more
wiley   +1 more source

High atmospheric pressure rescues plant growth under humidity stress: A model for climate‐resilient deep underground agriculture

Deep Underground Science and Engineering, EarlyView.
High atmospheric pressure (120 kPa) in deep underground counteracts humidity‐induced physiological stress in plants, stabilizing water balance and enhancing antioxidative defenses. This synergy boosts biomass despite elevated humidity, demonstrating sustainable deep underground agriculture potential under climate uncertainty.
Yuxin He, Linglu Xu, Xiao Tan, Wenhua Zhuang, Naiwen Li, Chao Liu, Bo Tan   +6 more
wiley   +1 more source