Results 171 to 180 of about 5,513,522 (257)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Research on carbon emission models and emission characteristics in the coal development process. [PDF]

Sci Rep
Gang W, Enguo W, Fukai Z, Minfu L, Ningning C, Haotian F, Dexing H, Yang S.   +7 more
europepmc   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Quantitative assessment of lung mechanical properties in ARDS using X-ray computed tomography. [PDF]

Intensive Care Med Exp
Gao J, Garberi R, Akor EA, Perchiazzi G, Kaczka DW.   +4 more
europepmc   +1 more source

From Responsibility to Resilience to Social Innovation: A Cyclical Theory of Responsible Networked Resilience in External Crises

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT External crises unsettle resources, routines, and what responsible action means. Prior research links CSR to stakeholder support and resilience. Yet these relationships remain fragmented, leaving mechanisms connecting responsibility, inter‐organizational cooperation, resilience, social innovation, and renewed responsibility expectations under ...
Darine Azzam
wiley   +1 more source

Development and validation of an interpretable machine learning model for predicting enteral nutrition-associated diarrhea in ICU patients: a multicenter study. [PDF]

Front Nutr
Wang Y, Hu W, Xu C, Zhang X, Chai F, Ji Y, Xu D, Li X.   +7 more
europepmc   +1 more source

Fracture evolution of a thick soft protection layer and the water inrush mechanism in overburden under longwall mining

Deep Underground Science and Engineering, EarlyView.
Through shear–tensile creep tests and viscoelastic modeling, the fracture evolution of thick soft protective layers is clarified. Results show thickness‐dependent rheological failure modes that govern four types of roof water inrush, providing a mechanism‐based framework for hazard prediction and control. Abstract In the Jurassic coal‐bearing strata of
Mengnan Liu, Wei Qiao, Xianggang Cheng, Xiangsheng Meng, Peichao Feng   +4 more
wiley   +1 more source

Feasibility Evaluation of a Standalone Virtual Reality System for Neonatal Resuscitation Training. [PDF]

J Med Syst
Amari S, Eto M, Oyama H.
europepmc   +1 more source

High atmospheric pressure rescues plant growth under humidity stress: A model for climate‐resilient deep underground agriculture

Deep Underground Science and Engineering, EarlyView.
High atmospheric pressure (120 kPa) in deep underground counteracts humidity‐induced physiological stress in plants, stabilizing water balance and enhancing antioxidative defenses. This synergy boosts biomass despite elevated humidity, demonstrating sustainable deep underground agriculture potential under climate uncertainty.
Yuxin He, Linglu Xu, Xiao Tan, Wenhua Zhuang, Naiwen Li, Chao Liu, Bo Tan   +6 more
wiley   +1 more source

Astaxanthin alleviates autophagy, inflammation, and oxidative stress in ventilator-associated lung injury rats by inhibiting MAPK/ERK1/2 pathway. [PDF]

Acta Cir Bras
Zhang J, Wei Y, Chen Z, Luo T, Cheng S, Wang J, Zhang X.   +6 more
europepmc   +1 more source