Results 171 to 180 of about 10,362,161 (244)

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu   +4 more
wiley   +1 more source

Timing of Tracheostomy and Risk of Ventilator-Associated Pneumonia in Patients Requiring Prolonged Mechanical Ventilation: A Case–Cohort Study with Time-to-Event Analysis

open access: green
Marié Nicoline Ordaz-Kücks   +10 more
openalex   +1 more source

Refining OVCAR‐3 xenograft models of peritoneal carcinomatosis in nu/nu mice: Comparative intraperitoneal implantation strategies and the role of basement membrane matrix

open access: yesAnimal Models and Experimental Medicine, EarlyView.
A refined murine model of advanced ovarian cancer was established by comparing localized preperitoneal implantation and intraperitoneal injection of OVCAR‐3Luc cells. While localized implantation showed limited tumor persistence, intraperitoneal delivery with BME produced sustained diffuse dissemination confirmed by BLI and histology, providing a ...
M. Teresa Perelló‐Trias   +5 more
wiley   +1 more source

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud   +3 more
wiley   +1 more source

Ventilator-Associated Events

open access: green
Marie-Céline Zanella   +2 more
openalex   +2 more sources

Impact of ventilator-associated events on clinical outcomes in mechanically ventilated patients: A retrospective cohort study from a Brazilian ICU [PDF]

open access: hybrid
Milena Siciliano Nascimento   +8 more
openalex   +1 more source

Borane‐Catalyzed Water Dehydrogenation at Dioxaphospholes and ‐Phospholanes

open access: yesAngewandte Chemie International Edition, EarlyView.
The borane‐catalyzed dehydrogenation of phenylphosphinate esters, which are formed from the reaction of dioxaphospholes and ‐phospholanes with water or air moisture under mild conditions, is reported. The mechanism of this transformation was investigated by kinetic measurements and DFT calculations, which indicate hydrogen elimination from a ...
Niklas Koch   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy