Results 51 to 60 of about 8,154,475 (178)

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Experimental ventilator-associated pneumonia: distribution of lung infection and consequences for lung aeration

Brazilian Journal of Infectious Diseases, 2003
Ventilator-associated pneumonia (VAP) has been described in humans and in experimental animals. The most severe lesions are located in dependent lung segments along a sterno-vertebral axis, however the cephalocaudal distribution of lung infection remains
Vieira Silvia Regina Rios, Goldstein Ivan, Lenaour Gilles, Marquette Charles-Hugo, Rouby Jean-Jacques   +4 more
doaj  

Ventilator-associated pneumonia prevention in the Intensive care unit using Postpyloric tube feeding in China (VIP study): study protocol for a randomized controlled trial

Trials, 2022
Background Ventilator-associated pneumonia is a challenge in critical care and is associated with high mortality and morbidity. Although some consensuses on preventing ventilator-associated pneumonia are reached, it is still somewhat controversial.
Linhui Hu, Kaiyi Peng, Xiangwei Huang, Zheng Wang, Quanzhong Wu, Yumei Xiao, Yating Hou, Yuemei He, Xinjuan Zhou, Chunbo Chen   +9 more
doaj   +1 more source

Chlorhexidine: The Fight to End Ventilator-Associated Pneumonia [PDF]

, 2020
There is a major problem that affects patient outcomes in the hospital setting. This problem is ventilator-associated pneumonia. Ventilator-associated pneumonia is the second most nosocomial infection in critical care patients.
Gaspari, Jeremy
core   +1 more source

Compliant hydrogel cuff coating with real‐time pressure monitoring and antibiofilm capabilities for ventilator‐associated pneumonia prophylaxis

BMEMat, EarlyView.
A soft‐compliant hydrogel cuff coating combines real‐time pressure monitoring with intrinsic antibacterial activity for prophylaxis of ventilator‐associated pneumonia. A flexible pressure‐sensing patch is embedded in the coating to enable wireless dynamic monitoring of endotracheal cuff pressure through Bluetooth.
Jin Chai, Yifu Tan, Jiaheng Liang, Shen Liu, Jiabin Zhao, Shanbo Ma, Chunxin Liu, Minghua Du, Mark Selvan, Xiaopeng Shi, Liqiang Song, Peng Li   +11 more
wiley   +1 more source

Ventilator-Associated Pneumonia Bundle Care [PDF]

, 2021
Ventilator-associated pneumonia (VAP) is one of the most significant nosocomial infections in intensive care units (ICU) worldwide. Patients who have this infection due to lengthy hospital stays face excessive hospital expenditures and are forced to ...
Binnichan, Jeemole Kattezham
core   +2 more sources

Biventricular Pressure‐Volume Loop Analysis in an LVAD Patient Optimized With Impella RP Flex

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Right ventricular (RV) failure after left ventricular assist device (LVAD) implantation is a serious complication which may necessitate temporary mechanical support in refractory cases. Here we describe a 63‐year‐old man with end‐stage ischemic cardiomyopathy and severe combined pre‐ and post‐capillary pulmonary hypertension who developed ...
Sara S. Inglis, Serena Rahme, Andrew N. Rosenbaum, Atta Behfar   +3 more
wiley   +1 more source

Oral hygiene care for critically ill patients to prevent ventilator associated pneumonia [Intervention Protocol]

, 2010
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effect of oral hygiene care on ventilator associated pneumonia (VAP) in critically ill patients receiving mechanical ventilation in hospital ...
Ng, Linda, Linda Ng, Helen V Worthington, Mervyn Singer, E Chen, Ian Needleman, Ping Wang, Wang, Ping, Needleman, Ian, Xie, Huixu, Huixu Xie, Yan Wu, Worthington, Helen, Wu, Yan, Singer, Mervyn, Zongdao Shi, Chen, E., Worthington, Helen V., Shi, Zongdao   +18 more
core   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Is HELICS the right way? Lack of chest radiography limits ventilator-associated pneumonia surveillance in Wales

Frontiers in Microbiology, 2016
Introduction: The reported incidence of ventilator-associated pneumonia (VAP) in Wales is low compared with surveillance data from other European regions.
Richard Pugh, Wendy Harrison, Susan Harris, Hywel Roberts, Gareth Scholey, Tamas Szakmany, Tamas Szakmany   +6 more
doaj   +1 more source