Results 211 to 220 of about 576,684 (304)

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Tetraventricular Hydrocephalus Due to Idiopathic Fourth Ventricle Outlet Obstruction: A Case Report and Literature Review. [PDF]

J Neurol Surg Rep
Singh G.
europepmc   +1 more source

Treatment of acute chronic obstructive pulmonary disease exacerbation improves right ventricle function [PDF]

, 2010
Murat Akçay, Ekrem Yeter, Tahir Durmaz, T. Keles, Nuri Bayram, Meral Uyar, Vedat Davutoğlu, İsa Öner Yüksel, Mustafa Kurt, Erhan Bozkurt   +9 more
openalex   +1 more source

Shannon Entropy of Gray Matter Eigenmodes: A Novel Biomarker for Alzheimer's Disease and Heterogeneous MCI Trajectories

Advanced Science, EarlyView.
Entropy derived from gray matter eigenmodes captures cortical disorganization in Alzheimer's disease. Using multimodal MRI and amyloid‐PET data, this novel structure–function coupling biomarker enables accurate classification of clinical stages, predicts Aβ burden, and stratifies mild cognitive impairment subtypes.
Yumeng Li, Gaoping Long, Xinyue Zhang, Kewei Chen, Xin Li, Zhanjun Zhang   +5 more
wiley   +1 more source

Predicting in-hospital indicators from wearable-derived signals for cardiovascular and respiratory disease monitoring: An in silico study. [PDF]

PLOS Digit Health
Laudenzi BM, Cucino A, Lassola S, Balzani E, Müller LO.   +4 more
europepmc   +1 more source

Atypical Obstructive Hydrocephalus Induced by Content Leakage from a Lateral Ventricle Epidermoid Cyst: A Case Report [PDF]

Antonio Victor Gouveia Azevedo dos Santos, Daislaine de Jesus Lima, Tarsila Stockler Ravaschieri Martinolli, Ricardo Sousa, Matheus Cardoso Aragão, E Cruz, Juan Pablo Montes, A. Rocha, Amanda Gomes Lima Bezerra, Laura Leme de Araujo Rodrigues da Silva, Juan Segundo‐Ramírez, Francisco Barbosa de Araújo Neto, Daniel Gurgel Fernandes Távora   +12 more
openalex   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Electroanatomical mapping-guided leadless pacemaker (MICRA-VR) implantation in the right atrium of a univentricular heart with Fontan circulation, an approach combining imaging and electrophysiology: insights from a case report. [PDF]

Eur Heart J Case Rep
Chevalier C, Rea O, Babouri N, Bessière F, Haddad C.   +4 more
europepmc   +1 more source

Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

Advanced Science, EarlyView.
The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang, Danni Zhou, Tianyi Zhu, Hao Wang, Xianzhen Chen, Lizhen Xu, Jun Su, Fan Yang, Yiquan Tang, Xuguang Li, Bing Yang, Lenan Zhuang, Wei Wang, Chenyang Jiang, Ping Liang   +23 more
wiley   +1 more source

Identifying Pathogenic Variants in Vietnamese Children with Functional Single Ventricle Based on Whole-Exome Sequencing. [PDF]

Diagnostics (Basel)
Tu LT, Lien NTK, Tung NV, Van DTH, Nga VQ, Tho NT, Hien NT, Duc NM, Hoang NH.   +8 more
europepmc   +1 more source