Results 241 to 250 of about 778,572 (398)

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Comparative accuracy evaluation of patient-specific 3D-printed guide and neuronavigation for ventriculoperitoneal shunt in dogs: a dual-phase <i>ex vivo</i> and <i>in vivo</i> study. [PDF]

Front Vet Sci
Jeon Y, Cho C, Jeong J, Meij B, Lee H.
europepmc   +1 more source

Influence of Age and Low Afterload on the Stress-Velocity Relation of the Left Ventricle [PDF]

, 1998
Daniël De Wolf, Dirk Matthys, Henri Verhaaren, Thierry Sluysmans   +3 more
openalex   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Reassessing chest compression sites in pediatric cardiopulmonary resuscitation without ventilatory support using echocardiographic assessment: a prospective observational study. [PDF]

Sci Rep
Suh D, Lee JH, Kwon H, Kim MJ.
europepmc   +1 more source

Where is the right ventricle?

BMJ Case Reports, 2014
M. Oylumlu, Adnan Dogan, S. Ercan, V. Davutoglu   +3 more
semanticscholar   +1 more source

Shannon Entropy of Gray Matter Eigenmodes: A Novel Biomarker for Alzheimer's Disease and Heterogeneous MCI Trajectories

Advanced Science, EarlyView.
Entropy derived from gray matter eigenmodes captures cortical disorganization in Alzheimer's disease. Using multimodal MRI and amyloid‐PET data, this novel structure–function coupling biomarker enables accurate classification of clinical stages, predicts Aβ burden, and stratifies mild cognitive impairment subtypes.
Yumeng Li, Gaoping Long, Xinyue Zhang, Kewei Chen, Xin Li, Zhanjun Zhang   +5 more
wiley   +1 more source

Mega Cisterna Magna: Current Perspectives and Future Directions-A Literature Review. [PDF]

Radiol Res Pract
Pishjoo M, Kheradmand D, Safdari M, Safdari Z, Mashhadinejad M.   +4 more
europepmc   +1 more source

The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension.

Chest, 2009
H. Bogaard, K. Abe, A. Vonk Noordegraaf, N. Voelkel   +3 more
semanticscholar   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source