Results 251 to 260 of about 585,278 (305)

Reconstructing Coherent Functional Landscape From Multi‐Modal Multi‐Slice Spatial Transcriptomics by a Variational Spatial Gaussian Process

Advanced Science, EarlyView.
This study introduces stVGP, a variational spatial Gaussian process framework for multi‐modal, multi‐slice spatial transcriptomics. By integrating histological and genomic data through hybrid alignment and attention‐based fusion, stVGP reconstructs coherent 3D functional landscapes.
Zedong Wang, Bowen Fu, Chuanchao Zhang, Xiaoping Liu   +3 more
wiley   +1 more source

Double inlet left ventricle in a 12-year-old European bison: a case report with anatomical assessment and postmortem computed tomography evaluation. [PDF]

BMC Vet Res
Godlewska A, Barszcz K, Przespolewska H, Bielecki W, Zabiega K, Buczyński M, Mądry W, Szymczak K, Kwiatkowska M, Grzegorczyk M, Szaluś-Jordanow O.   +10 more
europepmc   +1 more source

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

Mastering third ventricle surgery through anatomical laboratory knowledge. [PDF]

Surg Neurol Int
Serrano LANDA, Velázquez HOH, Anderson FJM, Borrero GES, Leguina ABR, Teyssandier M, Effgen EA, da Trindade ÉSGG, Filho JMC, Chaddad-Neto F.   +9 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

The stroke that unveiled a silent threat: rupture and thrombosis of hydatid cyst in the left ventricle- a case report. [PDF]

J Cardiothorac Surg
Es-Saad O, Abetti A, Belghit H, Darraz A, Alkouh R, Labib S.   +5 more
europepmc   +1 more source

Mitochondrial Transplantation as a Therapeutic Strategy for Inherited Mitochondrial Diseases

Advanced Science, EarlyView.
Mitochondrial transplantation (MTx) offers a promising therapeutic avenue for mitochondrial diseases. This review comprehensively evaluates MTx, differentiating its feasibility for mtDNA‐ and nDNA‐based disorders. It examines its potential for genetic correction, alongside inherent limitations, technical challenges, and crucial ethical considerations ...
Parmeshar Singh, Amir Tahavvori, Cyrus E. Kuschner, Blanca B. Espin, Jacob Kazmi, Sofhia V. Ramos, Tai Yin, Kei Hayashida, Kanako Ito‐Hagiwara, Yusuke Endo, Keitaro Yoshioka, Jun Hagiwara, Avijot Sohi, Alisha Oropallo, Ghania Haddad, Timmy Li, Lance B. Becker, Junhwan Kim   +17 more
wiley   +1 more source

IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells. [PDF]

Fluids Barriers CNS
Oviedo MJ, Ramírez E, De Lima I, Grondona JM, Cifuentes M, Martínez F, Barahona MJ, Nualart F, Salazar K.   +8 more
europepmc   +1 more source

Using deep learning to estimate systolic and diastolic volumes from MRI-images [PDF]

, 2016
Burms, Jeroen, Dambre, Joni, Degrave, Jonas, Korshunova, Iryna   +3 more
core   +1 more source

Trans-catheter aortic valve implantation in a patient with membranous ventricular septal defect, sub-aortic band and double-chambered right ventricle

Hirotsugu-Mitsuhashi
openalex   +1 more source