Results 321 to 330 of about 685,078 (425)

Refining the adriamycin‐induced focal segmental glomerulosclerosis mouse model to improve reproducibility and animal welfare

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study suggested the instability of Adriamycin (ADR) in aqueous solution as the main contributor to large ADR dose variations in literature of the ADR‐induced mouse model of focal segmental glomerulosclerosis (FSGS). We confirmed that freshly prepared ADR solution dosed at 10.5 mg/kg to be optimal in reliably producing FSGS pathology in BALB/c mice
Haochen Jiang   +8 more
wiley   +1 more source

Modeling Sporadic Progressive Supranuclear Palsy in 3D Midbrain Organoids: Recapitulating Disease Features for In Vitro Diagnosis and Drug Discovery

open access: yesAnnals of Neurology, EarlyView.
Objective Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease characterized by tangles of hyperphosphorylated tau protein and tufted astrocytes. Developing treatments for PSP is challenging due to the lack of disease models reproducing its key pathological features.
Elvira Immacolata Parrotta   +15 more
wiley   +1 more source

Subventricular Zone Microstructure in Pediatric‐Onset Multiple Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objective The aim of this study was to explore the microstructural dynamics of the subventricular zone (SVZ) with aging and their associations with clinical disability and brain structural damage in pediatric‐onset multiple sclerosis (MS) patients. Methods One‐hundred and forty‐one pediatric‐onset MS patients (67 pediatric and 74 adults with pediatric ...
Monica Margoni   +9 more
wiley   +1 more source

Adult Neurogenesis in the Subventricular Zone of Patients with Huntington's and Parkinson's Diseases and following Long‐Term Treatment with Deep Brain Stimulation

open access: yesAnnals of Neurology, EarlyView.
Objective Parkinson's and Huntington's diseases are characterized by progressive neuronal loss. Previous studies using human postmortem tissues have shown the impact of neurodegenerative disorders on adult neurogenesis. The extent to which adult neural stem cells are activated in the subventricular zone and whether therapeutic treatments such as deep ...
Marta Snapyan   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy