Results 61 to 70 of about 1,208,488 (310)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Prognostic impact of morphology and duration of premature ventricular contractions in a population without structural heart disease

Annals of Noninvasive Electrocardiology, 2023
Background Premature ventricular contractions (PVCs) are a common form of arrhythmia associated with an unfavorable prognosis in patients with structural heart disease. It is unclear whether PVCs site of origin and QRS‐width has a prognostic significance
Raffaele Scorza, Martin Jonsson, John‐Martin Corander, Mårten Rosenqvist, Viveka Frykman   +4 more
doaj   +1 more source

Three-dimensional echocardiography and 2D-3D speckle tracking imaging in chronic pulmonary hypertension. diagnostic accuracy in detecting hemodynamic signs of RV failure [PDF]

, 2015
Background and objective. Our aim was to compare three-dimensional (3D) and 2D and 3D speckle tracking (2D-STE, 3D-STE) echocardiographic parameters with conventional right ventricular (RV) indexes in patients with chronic pulmonary hypertension (PH ...
Alessia, Azzano, Capotosto, Lidia, Gaudio, Carlo, Mangieri, Enrico, Nino, Cocco, Rasul, Ashurov, Rosato, Edoardo, Salsano, Felice, Simona, D’Orazio, Terzano, Claudio, Truscelli, Giovanni, Vitarelli, Antonino   +11 more
core   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Ventricular Fibrillation [PDF]

, 2011
An unsteady baseline and a very irregular QRS segment are highly indicative of ventricular ...
Ginter, James F., Loftis, Patrick
core   +1 more source

Unusual Presentation of A Massive Pulmonary Embolism

Journal of Tehran University Heart Center, 2011
A pulmonary embolus clogs the artery that provides blood supply to a part of the lung. The embolus not only prevents the exchange of oxygen and carbon dioxide but also decreases blood supply to the lung tissue itself, potentially causing the tissue to ...
Morteza Safi, Reza Tajik Rostami, Maryam Taherkhani   +2 more
doaj  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

The involvement of Rcc2 in mammalian neurogenesis [PDF]

, 2016
Rcc2 is a Rac guanine nucleotide exchange factor recently identified as a principal signaling component of integrin adhesion complexes that also plays a central role in the completion of mitosis and cytokinesis.
Yanushefski, Lisa
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Six-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy [PDF]

, 2018
Background: In patients with ischaemic left ventricular dysfunction, coronary artery bypass surgery (CABG) may decrease mortality, but it is not known whether CABG improves functional capacity.
Al-Khalidi, Hussein R., Cleland, John G.H., Desvigne-Nickens, Patrice, Drazner, Mark H., Jasinski, Marek, Kosevic, Dragana, Leng, Chua Yeow, Mark, Daniel B., Petrie, Mark C., Rajda, Miroslaw, Roy, Ambuj, Rynkiewicz, Andrzej, Stebbins, Amanda, Stewart, Ralph A.H., Szalewska, Dominika, Tungsubutra, Wiwun, Velazquez, Eric J., White, Harvey D.   +17 more
core   +1 more source