Results 211 to 220 of about 165,259 (299)

Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement: A meta‐analysis

open access: yesPrecision Medical Sciences, EarlyView.
Central illustration: Sex‐based differences in outcomes between male and female patients with bicuspid aortic stenosis following transcatheter aortic valve replacement. Abstract Bicuspid aortic valve (BAV) is a common congenital anomaly leading to early aortic stenosis.
Muhammad Huzaifa Ahmed Khan   +12 more
wiley   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Optimization of Outflow-Tract Ventricular Arrhythmia Ablation Using a Universal Right Ventricle Model. [PDF]

open access: yesJ Cardiovasc Dev Dis
Szkoła K   +5 more
europepmc   +1 more source

Role of novel automated methods in pulse signal analysis to screen for sleep‐disordered breathing among patients on chronotropic medications

open access: yesSleep Research, EarlyView.
Abstract Study objectives To investigate the use of automated analysis to detect heart rate accelerations (HRAs) to screen for sleep‐disordered breathing (SDB) among patients who use chronotropic medications. Methods Nocturnal polysomnography (NPSG) recordings from 933 participants in the Sleep Heart Health Study were analyzed using an automated method
Nabila Ahmed   +11 more
wiley   +1 more source

Lysosomal Ca<sup>2+</sup> Release Through TRPML1 Governs Ventricular Arrhythmia After Myocardial Infarction. [PDF]

open access: yesCirc Arrhythm Electrophysiol
Xie A   +6 more
europepmc   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min   +3 more
wiley   +1 more source

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