Results 61 to 70 of about 449,883 (300)

Arrhythmias in Patients With Valvular Heart Disease: Gaps in Knowledge and the Way Forward

Frontiers in Cardiovascular Medicine, 2022
The prevalence of both organic valvular heart disease (VHD) and cardiac arrhythmias is high in the general population, and their coexistence is common. Both VHD and arrhythmias in the elderly lead to an elevated risk of hospitalization and use of health ...
Maciej Kubala, Maciej Kubala, Christian de Chillou, Yohann Bohbot, Yohann Bohbot, Patrizio Lancellotti, Maurice Enriquez-Sarano, Christophe Tribouilloy, Christophe Tribouilloy   +8 more
doaj   +1 more source

Altered Calcium Handling and Ventricular Arrhythmias in Acute Ischemia

, 2016
Acute ischemia results in deadly cardiac arrhythmias that are a major contributor to sudden cardiac death (SCD). The electrophysiological changes involved have been extensively studied, yet the mechanisms of ventricular arrhythmias during acute ischemia ...
T. Alexander Quinn, Peter Baumeister
core   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Recent advances in the management of ventricular tachyarrhythmias [version 1; referees: 2 approved]

F1000Research, 2017
Ventricular arrhythmias are an important cause of cardiovascular morbidity and mortality, particularly in those with structural heart disease, inherited cardiomyopathies, and channelopathies. The goals of ventricular arrhythmia management include symptom
Syeda Atiqa Batul, Brian Olshansky, John D. Fisher, Rakesh Gopinathannair   +3 more
doaj   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Electrocardiographic Patterns of Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Frontiers in Physiology, 2012
Ventricular arrhythmias in patients with ARVD/C are common. Differentiation between idiopathic ventricular tachycardia and arrhythmogenic right ventricular dysplasia is of utmost importance.
Kurt eHoffmayer, Melvin M Scheinman
doaj   +1 more source

Iron Deposition following Chronic Myocardial Infarction as a Substrate for Cardiac Electrical Anomalies: Initial Findings in a Canine Model [PDF]

, 2013
Purpose: Iron deposition has been shown to occur following myocardial infarction (MI). We investigated whether such focal iron deposition within chronic MI lead to electrical anomalies. Methods: Two groups of dogs (ex-vivo (n = 12) and in-vivo (n = 10))
Cokic Ivan, Stewart Brian, Tang, Richard, Cokic, Ivan, Wang Xunzhang, Allen M Amorn, Thajudeen, Anees, Bennett, Nathan, Richard L Q Tang, Nathan Bennett (459351), Amorn, Allen M., Sotirios A Tsaftaris, Bennett Nathan, Harlev Doron, Thajudeen Anees, Tsaftaris Sotirios A., Chugh, Sumeet S., Brian Stewart, Harlev, Doron, Allen M. Amorn (459348), Sumeet S. Chugh (215629), Tsaftaris, Sotirios A., Shehata Michael, Xunzhang Wang, Rohan Dharmakumar (459355), Chugh Sumeet S., Dharmakumar Rohan, Doron Harlev, Hsin-Jung Yang, Yang, Hsin-Jung, Amorn Allen M., Brian Stewart (459350), Wang, Xunzhang, Avinash Kali, Enzhao Liu, Nathan Bennett, Avinash Kali (459342), Warren M. Jackman (459354), Michael Shehata, Richard L. Q. Tang (459345), Tang Richard L. Q., Hsin-Jung Yang (459344), Michael Shehata (459347), Warren M Jackman, Jackman Warren M., Liu Enzhao, Liu, Enzhao, Sotirios A. Tsaftaris (459353), Ivan Cokic (459341), Rohan Dharmakumar, Stewart, Brian, Sumeet S Chugh, Ivan Cokic, Anees Thajudeen, Enzhao Liu (459349), Yang Hsin-Jung, Dharmakumar, Rohan, Jackman, Warren M., Kali, Avinash, Doron Harlev (459352), Shehata, Michael, Anees Thajudeen (459346), Kali Avinash, Xunzhang Wang (459343)   +63 more
core   +2 more sources

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Estudio de los mecanismos de las arritmias cardiacas mediante modelado y procesado robusto digital de señal [PDF]

, 2008
Las arritmias cardiacas son alteraciones del funcionamiento eléctrico normal del corazón. Algunas, las arritmias patológicas, son potencialmente malignas y constituyen una de las principales causas de mortalidad en el mundo occidental.
Alonso Atienza, Felipe
core   +1 more source