Results 91 to 100 of about 43,719 (293)

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

Lawn Mower Versus Left Ventricular Assist Device

JACC: Case Reports, 2020
A 77-year-old man with history of ischemic cardiomyopathy and left ventricular assist device (LVAD) presented with abdominal pain after a lawn mower accident.
Vishal N. Rao, MD, MPH, Marat Fudim, MD, MHS, Andrew Griffin, MD, Jennifer A. Rymer, MD, MBA, W. Schuyler Jones, MD, Lynne M.H. Koweek, MD, Tony P. Smith, MD, Daniele Marin, MD, Adam D. DeVore, MD, MHS   +8 more
doaj  

Towards the Development of a Pediatric Ventricular Assist Device

Cell Transplantation, 2006
The very limited options available to treat ventricular failure in children with congenital and acquired heart diseases have motivated the development of a pediatric ventricular assist device at the University of Pittsburgh (UoP) and University of ...
Harvey S. Borovetz P.HD, Stephen Badylak, J. Robert Boston, Carl Johnson, Robert Kormos, Marina V. Kameneva, Marwan Simaan, Trevor A. Snyder, Hiro Tsukui, William R. Wagner, Joshua Woolley, James Antaki, Chenguang Diao, Stijn Vandenberghe, Bradley Keller, Victor Morell, Peter Wearden, Steven Webber, Jeff Gardiner, Chung M. Li, Dave Paden, Bradley Paden, Shaun Snyder, Jingchun Wu, Gill Bearnson, John A. Hawkins, Gordon Jacobs, John Kirk, Pratap Khanwilkar, Peter C. Kouretas, James Long, R. E. Shaddy   +31 more
doaj   +1 more source

Depth‐Customizable 3D Electrode Array for Recording Functional Connectivity in the Brain

Advanced Electronic Materials, EarlyView.
In this study, a depth‐adjustable, flexible 3D multi‐shank electrode array that produces precise neural recordings at various brain depths is developed. Integrating 2D flexible electrode arrays with a modular supporting board allowed the insertion depth to be easily adjusted without re‐fabrication.
Minseok Kim, Sehwan Park, Haeyun Lee, Jimin Lee, Namsun Chou, Hyogeun Shin   +5 more
wiley   +1 more source

Knowledge, Attitude, and Practice on Atrial Fibrillation and Atrial Fibrillation Screening in High‐Risk Population: A Cross‐Sectional Study

AGING MEDICINE, EarlyView.
Distribution of KAP scores for participants ≤ 65 versus > 65 years. ABSTRACT Objectives Atrial fibrillation (AF) is a common clinical arrhythmia. Failure to identify AF leaves patients at a considerably higher risk of disability and death, making its early screening and prevention extremely important. This study aimed to investigate knowledge, attitude,
Zhong Yi, Xinxin Yan, Shaozhi Xi, Lijuan Zhu, Rui Liu, Jing Li, Songwei Ru, Xiu Zheng, Jingxuan Qiu, Chunqi Wang, Na Guo, Yimin Wang, Dayong Gao   +12 more
wiley   +1 more source

Improved Results for Postcardiotomy Cardiogenic Shock With the Use of Implantable Left Ventricular Assist Devices [PDF]

, 1997
Joseph J. DeRose, Juan P. Umaña, Michael Argenziano, Katharine A. Catanese, Howard R. Levin, Benjamin Sun, Eric A. Rose, Mehmet C. Öz   +7 more
openalex   +1 more source

Design, Modeling, and Control of a Soft Robotic Diaphragm‐Assist Device in a Respiratory Simulator

Advanced Intelligent Systems, Volume 7, Issue 7, July 2025.
A soft robotic diaphragm‐assist device using fabric‐based pneumatic actuators with a 2‐step control system to optimize synchronization and support is introduced. This system can detect the initiation of breathing to trigger assistance and regulate pressures to provide the correct level of inhalation augmentation. Validation and testing are completed on
Diego Quevedo‐Moreno, Sang‐Yoep Lee, Jonathan Tagoe, Vishnu Emani, Jean Bonnemain, Ellen T. Roche   +5 more
wiley   +1 more source

E‐CAD: Electroactive Polymer‐Based Cardiac Assist Device with Low Power Consumption

Advanced Intelligent Systems, EarlyView.
Conventional cardiac assist devices often require high power, involve direct blood contact, and risk driveline infections. This work presents a soft electroactive polymer‐based system that compresses the heart externally while consuming <0.3 W. With no blood contact, a 0.3 mm driveline, and a compact design, E‐CAD demonstrates enhanced output and ...
Jiyeop Kim, Junheon Lee, Sein Song, Si‐Hyuck Kang, Amy Kyungwon Han   +4 more
wiley   +1 more source

Surgical Outcomes of Centrifugal Continuous-Flow Implantable Left Ventricular Assist Devices: Heartmate 3 versus Heartware Ventricular Assist Device

Journal of Chest Surgery
Background: Left ventricular assist devices (LVADs) are widely employed as a therapeutic option for end-stage heart failure. We evaluated the outcomes associated with centrifugal- flow LVAD implantation, comparing 2 device models: the Heartmate 3 (HM3)
Kinam Shin, Won Chul Cho, Nara Shin, Hong Rae Kim, Min-Seok Kim, Cheol Hyun Chung, Sung-Ho Jung   +6 more
doaj   +1 more source