Results 81 to 90 of about 43,719 (293)
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Advanced Science, EarlyView.This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai +9 more
wiley +1 more source
Advanced Science, Volume 12, Issue 28, July 24, 2025.This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu +7 more
wiley +1 more source
Advanced Science, EarlyView.By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang +10 more
wiley +1 more source
Left Ventricular Assist Device Outflow Cannula Obstruction
JACC: Case Reports, 2020 One of the dreaded complications of left ventricular assist device implantation is mechanical obstruction of the device secondary to pump thrombosis or mechanical outflow cannula obstruction.
Majid Asawaeer, MD +4 more
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Advanced Science, Volume 12, Issue 28, July 24, 2025.A wireless‐charging sustained oxygen release from conductive microgels (SOCO) served as an antenna and an on‐demand O2 release for nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic oxygen release and electrical stimulation to promote the reconstruction of blood
Hoi Man Iao +15 more
wiley +1 more source
Advanced Science, EarlyView.This study addresses a critical gap in ultrafast ultrasound cardiovascular flow imaging and introduces a transformative approach, Clustering Singular Value Decomposition (cSVD), which enables dynamic cardiovascular flow imaging throughout full cardiac cycle without motion correction and hyper‐fast imaging strategies.
Hao Yu +6 more
wiley +1 more source
Critical Care Transthoracic Echocardiography
Journal of Investigative Medicine High Impact Case Reports, 2014 A 70-year-old man with end-stage heart failure and a continuous-flow left ventricular assist device received repeated electrical discharges from his biventricular implantable cardiac defibrillator.
Peter Mark Schulman MD +5 more
doaj +1 more source
Advanced Science, EarlyView.A flexible piezoresistive pressure sensor with dual‐graded microstructures achieves both high sensitivity (69.8 kPa⁻¹) and a broad linear range up to 300 kPa (R2 = 0.997). Synergizing structural deformation and tunneling conduction, it enables rapid, stable, and accurate detection of subtle physiological signals, offering a scalable and cost‐effective ...
Ningning Bai +11 more
wiley +1 more source
JTCVS Open, 2022 Objective: Chronic kidney disease and renal failure are common in patients being considered for left ventricular assist device support. We sought to evaluate the outcomes of patients undergoing left ventricular assist device implantation with ...
J. Hunter Mehaffey, MD, MSc +9 more
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