Results 91 to 100 of about 234,679 (371)

Mechanical chest-compression devices: current and future roles [PDF]

, 2010
Purpose of review: It is recognised that the quality of CPR is an important predictor of outcome from cardiac arrest yet studies consistently demonstrate that the quality of CPR performed in real life is frequently sub-optimal.
Brace, Samantha J., Gates, Simon, Perkins, Gavin D.   +2 more
core   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

A Short Review of Advances in the Modelling of Blood Rheology and Clot Formation [PDF]

, 2017
Several advances have taken place since the early 2000s in the field of blood flow modelling. These advances have been driven by the development of assist devices such as Left Ventricular Assist Devices (LVADs), etc., and by the acceptance of in silico ...
Mohan, Anand, Rajagopal, K R
core   +1 more source

Two implantable continuous-flow ventricular assist devices in a biventricular configuration: technique and results.

Interactive Cardiovascular and Thoracic Surgery, 2018
OBJECTIVES No continuous-flow right ventricular assist device for long-term support is available at the moment. Two continuous-flow ventricular assist devices used in a continuous-flow biventricular assist device configuration is an emerging option which
J. Eulert-Grehn, Pia Lanmüller, F. Schönrath, N. Solowjowa, M. Müller, J. Mulzer, F. Kaufmann, C. Starck, T. Krabatsch, V. Falk, E. Potapov   +10 more
semanticscholar   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Future of smart cardiovascular implants [PDF]

, 2018
Cardiovascular disease remains the leading cause of death in Western society. Recent technological advances have opened the opportunity of developing new and innovative smart stent devices that have advanced electrical properties that can improve ...
Bussooa, Anubhav, Mercer, John R., Neale, Steven   +2 more
core   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Left Ventricular Assist Devices – Past, Present, and Future: A Narrative Review

Journal of the Practice of Cardiovascular Sciences
Advanced heart failure (AHF) is a major problem with an aging population and profound unmet needs. While heart transplant offers the most definitive solution, it is largely unavailable for most and mandates a long waiting period.
Devesh Kumar, Sandeep Seth, Rajiv Narang
doaj   +1 more source

Improving Postdischarge Outcomes in Acute Heart Failure [PDF]

, 2018
The global burden that acute heart failure (AHF) carries has remained unchanged over the past several decades (1). European registries (2–5) showed that 1-year outcome rates remain unacceptably high (Table 1) and confirm that hospitalization for AHF ...
Ambrosy, Andrew P., Antohi, Elena-Laura, Butler, Javed, Chioncel, Ovidiu, Collins, Sean P., Iliescu, Vlad Anton, Maggioni, Aldo P., Mebazaa, Alexandre, Pang, Peter S.   +8 more
core   +1 more source

Risk factors for stroke on left ventricular assist devices

Journal of cardiac surgery, 2018
Patients with end‐stage heart failure on left ventricular assist devices (LVADs) are predisposed to a high incidence of stroke. Preoperative factors associated with increased stroke risk are poorly understood.
M. Bishawi, Jeremy T. Joseph, C. Patel, J. Schroder, M. Daneshmand, D. Bowles, J. Rogers, C. Milano   +7 more
semanticscholar   +1 more source