Results 111 to 120 of about 728,109 (348)

Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1

Advanced Science, EarlyView.
The study identifies a novel mechanistic link between long‐term HS diet and cognitive impairment, wherein PKA/CREB axis inactivation leads to SHANK1 reduction, synaptic damage, and cognitive deficits. Abstract High‐salt (HS) diet is an established risk factor for cognitive impairment, but the underlying mechanisms remain unclear.
Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jianzhi Wang, Rong Liu, Wei Liu, Hui Shen, Xiaochuan Wang   +10 more
wiley   +1 more source

TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease [PDF]

, 2018
Hemodynamic collapse and myocardial dysfunction are among the major causes ofdeath in severe sepsis. The purpose of this study was to assess the role played by TLR4and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after ...
Branda, Hugo Justino, Carvalho, Adriana Bastos, Fernandez Ruocco, Maria Julieta, Ferreira, Fabiano, López Alarcón, Maria Micaela, Medei, Emiliano, Neto Paiva, Claudia, Paula Neto, Heitor A., Peroba Ramos, Isalira, Sepúlveda, Marisa Noemí, Vila Petroff, Martin Gerarde   +10 more
core   +2 more sources

Asymptomatic Left Ventricular Dysfunction [PDF]

JACC: Heart Failure, 2016
Heart failure (HF) is a syndrome, the progressive nature of which is well recognized. The guidelines emphasize the importance of its early, preclinical stages and divide the disorder into 4 stages [(1)][1]. Two stages (A and B) are asymptomatic.
openaire   +2 more sources

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

An effect of left ventricular hypertrophy on mild-to-moderate left ventricular diastolic dysfunction

Hellenic Journal of Cardiology, 2016
Objectives: Left ventricular diastolic dysfunction (LVDD) is associated with a variety of medical conditions. Left ventricular hypertrophy (LVH) is one of the most common abnormalities that induce LVDD.
Sharma Kattel, MD, Salim Memon, MBBS, Keiko Saito, MD, Jagat Narula, MD, PhD, Yuji Saito, MD, PhD   +4 more
doaj   +1 more source

Left Heart Factors in Embolic Stroke of Undetermined Source in a Multiethnic Asian and North African Cohort

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Cardiac features diverge in Asians; however, it is not known how these differences relate to embolic stroke of unknown source (ESUS) in Southeast Asian and Eastern Mediterranean regions.
Saadat Kamran, Rajvir Singh, Naveed Akhtar, Pooja George, Abdul Salam, Blessy Babu, Ahmed Own, Tahir Hamid, Jonathan D. Perkins   +8 more
doaj   +1 more source

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. [PDF]

, 2019
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population.
Alex, Linda, Baines, Christopher P, Domeier, Timothy L, Edwards, Jenna C, Emter, Craig A, Ferreira-Nichols, Stephanie C, Ford, David A, Gao, Chen, Ivey, Jan R, Jones, John L, Jurrissen, Thomas J, Klutho, Paula J, Krenz, Maike, McDonald, Kerry S, Olver, T Dylan, Padilla, Jaume, Rau, Christoph, Rector, R Scott, Solaro, R John, Thorne, Pamela K, Veteto, Adam B, Wang, Yibin, Warren, Chad M   +22 more
core  

Prospective evaluation of smartwatch-enabled detection of left ventricular dysfunction

Nature Network Boston, 2022
Z. Attia, D. Harmon, Jennifer Dugan, L. Manka, F. Lopez‐Jimenez, Amir Lerman, K. Siontis, P. Noseworthy, Xiaoxi Yao, Eric W. Klavetter, J. Halamka, S. Asirvatham, Rita G. Khan, R. Carter, B. Leibovich, P. Friedman   +15 more
semanticscholar   +1 more source

Red Blood Cell Membrane Lipidomics: Potential Biomarkers Detecting Method for Plasma Volume Overload and Major Adverse Cardiovascular Events in Chronic Heart Failure Patients

Advanced Science, EarlyView.
A novel RBC indicator, ESI, is better than the traditional RBC indicators and is associated with CHF prevalence and in‐hospital death. RBC membrane lipidomics, Cer 18:0;O2/16:0, and LPE 18:0, are associated with plasma volume overload and MACE in CHF patients, but these plasma lipids could not.
Lin Zhang, Xiangqin Ou, Jingyi Lin, Xiaofei Luo, Jiashun Zhou, Xingyue Zhou, Peihua Zhao, Li Liu, Ziran Zhao, Ying Zhou, Guanwei Fan, Lifeng Han, Xiumei Gao   +12 more
wiley   +1 more source

The effect of cardiac resynchronization on morbidity and mortality in heart failure [PDF]

, 2005
Background: Cardiac resynchronization reduces symptoms and improves left ventricular function in many patients with heart failure due to left ventricular systolic dysfunction and cardiac dyssynchrony.
Cleland, John G.F., Daubert, Jean-Claude, Erdmann, Erland, Freemantle, Nick, Gras, Daniel, Kappenberger, Lukas, Tavazzi, Luigi   +6 more
core   +1 more source