Results 121 to 130 of about 365,117 (308)
Advanced Science, EarlyView.A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang +8 more
wiley +1 more source
Fenofibrate prevents isoproterenol-induced left ventricular hypertrophy and pump dysfunction in rats [PDF]
, 2011 MSc (Med), University of the Witwatersrand, Faculty of Health Sciences, School of PhysiologyThe role of metabolic remodelling in heart failure is not fully understood, significant evidence has accumulated to suggest that it may be central to the ...
Maswanganyi, Tlangelani
core
Advanced Science, EarlyView.This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu +11 more
wiley +1 more source
Advanced Science, EarlyView.A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra +23 more
wiley +1 more source
Advanced Science, EarlyView.This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen +8 more
wiley +1 more source
Differential right and left ventricular diastolic tolerance to acute afterload and NCX gene expression in Wistar rats [PDF]
, 2006 This study evaluated right ventricular (RV) and left ventricular (LV) diastolic tolerance to afterload and SERCA2a, phospholamban and sodium-calcium exchanger (NCX) gene expression in Wistar rats.
Correia-Pinto J +3 more
core
Advanced Science, EarlyView.Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li +11 more
wiley +1 more source
Advanced Science, EarlyView.In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen +17 more
wiley +1 more source
SEVERE POSTDUCTAL COARCTATION OF AORTA PRESENTING LIKE IDIOPATHIC DILATED CARDIOMYOPATHY
Gomal Journal of Medical Sciences, 2017 Left ventricular systolic dysfunction in childhood can be due to many causes. It may be because of sequel of myocarditis, metabolic causes, storage disorder, congenital heart disease or idiopathic dilated cardiomyopathy.
Sandip Ghosh +4 more
doaj
Advanced Science, EarlyView.Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan +6 more
wiley +1 more source