Results 91 to 100 of about 281,096 (294)

Preoperative Evaluation and Perioperative Complications in Patients with Cancer and Ventricular Dysfunction [PDF]

, 2022
Aurora Felice Castro Issa, G Zagni, Vithoria Vidotti, Tereza Cristina Felippe Guimarães, M. Santos, Carolina Maria Pinto Domingues Carvalho Silva   +5 more
openalex   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Taurine-magnesium Coordination Compound Attenuates Hypoxia/Reoxygenation Induced Ion Channel Dysfunction in Rat Ventricular Myocytes [PDF]

, 2013
Lin Zhao, Jie Lou, Yi Kang
openalex   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Temperature Trajectories Correlate With Cardiac Function in Patients With Sepsis

Critical Care Explorations
OBJECTIVES:. Body temperature trajectories of infected patients are associated with dynamic clinical and immune responses to infection. Our objective was to evaluate the association between temperature trajectory subphenotypes and cardiac dysfunction ...
Annabel H. Lu, MD, Vardhmaan Jain, MD, Po-Han Chen, MD, Matthew M. Churpek, MD, PhD, Philip A. Verhoef, MD, PhD, Arshed A. Quyyumi, MD, FRCP, Sivasubramanium V. Bhavani, MD, MS   +6 more
doaj   +1 more source

Moderate aortic valve stenosis in patients with left ventricular systolic dysfunction—insights on prognosis and the potential role of early aortic valve replacement [PDF]

, 2017
Chetan Huded, Milind Y. Desai
openalex   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

The association of serum vitamin D concentration and ventricular dysfunction among patients with acute coronary syndrome

Therapeutics and Clinical Risk Management, 2017
Kamal Khademvatani,1 Mirhosein Seyed Mohammadzad,1 Zahra Yekta,2 Omid Hadizadeh1 1Department of Cardiology, Shohada Hospital, 2Department of Community and Preventive Medicine, Urmia University of Medical Sciences, Urmia, Iran Objective: To determine if
Khademvatani K, Mohammadzad MS, Yekta Z, Hadizadeh O   +3 more
doaj