Results 101 to 110 of about 281,096 (294)

Left atrial membrane, left ventricular dysfunction, and mitral regurgitation in an adult [PDF]

, 2005
Abdulaziz Alkhulaifi, O Altamimi, C S Carr   +2 more
openalex   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Right ventricular diastolic dysfunction and postoperative cardiac complications in patients undergoing coronary artery bypass grafting [PDF]

, 2021
А. Н. Сумин, Е В Корок, Tatiana Yu. Sergeeva   +2 more
openalex   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Melody Valve Implantation Into the Branch Pulmonary Arteries for Treatment of Pulmonary Insufficiency in an Ovine Model of Right Ventricular Outflow Tract Dysfunction Following Tetralogy of Fallot Repair [PDF]

, 2011
J. Daniel Robb, Matthew A. Harris, Masahito Minakawa, Evelio Rodríguez, Kevin J. Koomalsingh, Takashi Shuto, David Shin, Yoav Dori, Andrew C. Glatz, Jonathan J. Rome, Robert C. Gorman, Joseph H. Gorman, Matthew J. Gillespie   +12 more
openalex   +1 more source

Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging [PDF]

, 2021
Thomas H. Marwick, Alessia Gimelli, Sven Plein, Jeroen J. Bax, Philippe Charron, Victoria Delgado, Erwan Donal, Patrizio Lancellotti, Eylem Levelt, Pál Maurovich‐Horvat, Stefan Neubauer, Gianluca Pontone, Antti Saraste, Bernard Cosyns, Thor Edvardsen, Bogdan A. Popescu, Maurizio Galderisi, Geneviève Dérumeaux, Magnus Bäck, Philippe B. Bertrand, Marc R. Dweck, Niall Keenan, Julien Magné, Danilo Neglia, Ivan Stanković   +24 more
openalex   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source

Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis [PDF]

, 2022
Jan Stassen, See Hooi Ewe, Steele C. Butcher, Mohammed Amanullah, Bart Mertens, Kensuke Hirasawa, Gurpreet K. Singh, Kenny Yoong Kong Sin, Zee Pin Ding, Stephan Milhorini Pio, Ching‐Hui Sia, Nicholas Chew, William Kong, Kian Keong Poh, David J. Cohen, Philippe Généreux, Martin B. Leon, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax   +19 more
openalex   +1 more source