Results 171 to 180 of about 570,572 (255)

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Idiopathic Ventricular Fibrillation Triggered by Purkinje-Related Extrasystoles: State-of-the-Art and Novel Therapeutic Approaches. [PDF]

J Cardiovasc Electrophysiol
Mugnai G, Genovese D, Santoro F, Di Biase L, Zou F, Tomasi L, de Asmundis C, Ribichini F, Brugada P, Chierchia GB.   +9 more
europepmc   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions

Phytotherapy Research, EarlyView.
Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli, Ivan Corazza, Roberta Budriesi, Luca Camarda, Maria Carelli, Alberto Spadotto, Igor Diemberger   +6 more
wiley   +1 more source

BMIPP Imaging in Out-of-Hospital Cardiac Arrest: Exercise-Induced Vasospastic Angina With Ventricular Fibrillation. [PDF]

JACC Case Rep
Aikawa H, Murai K, Seiki S, Sawano H, Kobayashi M, Hirooka K, Hayashi Y, Ito Y.   +7 more
europepmc   +1 more source

Sleep‐disordered breathing in valvular heart disease: A Modifiable comorbidity

Sleep Research, EarlyView.
Abstract Sleep‐disordered breathing (SDB) is highly prevalent among patients with valvular heart disease (VHD) and is independently associated with adverse clinical outcomes. The two major phenotypes—obstructive sleep apnea (OSA) and central sleep apnea (CSA)—exhibit distinct distributions across VHD subtypes. CSA predominates in severe aortic stenosis,
Wu Juan, Chen Ze, Zhang Qun, Chen Qiuyuan, Su Mei, Zhang Xilong, Ding Ning   +6 more
wiley   +1 more source

Recurrent Ventricular Fibrillation Induced by a Mobile Thrombus in the Sinus of Valsalva in a Patient With Bipolar Disorder. [PDF]

Cureus
Kobayashi K, Mizuno Y, Yusa H.
europepmc   +1 more source

ECG‐TransCovNet: A hybrid transformer model for accurate arrhythmia detection using Electrocardiogram signals

CAAI Transactions on Intelligence Technology, EarlyView.
Abstract Abnormalities in the heart's rhythm, known as arrhythmias, pose a significant threat to global health, often leading to severe cardiac conditions and sudden cardiac deaths. Therefore, early and accurate detection of arrhythmias is crucial for timely intervention and potentially life‐saving treatment.
Hasnain Ali Shah, Faisal Saeed, Muhammad Diyan, Nouf Abdullah Almujally, Jae‐Mo Kang   +4 more
wiley   +1 more source

Mechanistic interpretations of sustained ventricular fibrillation: The role of mapping methodology, model and time. [PDF]

Heart Int
Tonko JB, Kappadan V, El-Medany A, Aggour H, Zhen H, Birdi A, Pyman E, Barker J, Guichard JB, Clayton RH, Ng FS.   +10 more
europepmc   +1 more source

The distance between hospitals

Journal of Hospital Medicine, EarlyView.
Carrie A. Sailer
wiley   +1 more source