Results 41 to 50 of about 8,670,383 (247)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Evaluation of left ventricular function in patients with chronic obstructive pulmonary disease with or without pulmonary hypertension

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Background: Chronic obstructive pulmonary disease (COPD) is a common entity in clinical practice. Development of right ventricular hypertrophy and eventual right side heart failure is also common in such patients.
Rabab A. El Wahsh, Mahmoud K. Ahmed, Rehab I. Yaseen   +2 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Improvement of left ventricular systolic function after intervention on right ventricular hemodynamics

Annals of Pediatric Cardiology
Background: The importance of right–left ventricular interactions is increasingly recognized in patients with congenital heart disease. Interventions to improve right ventricular volume/pressure overloading may result in improvement of left ventricular ...
James Wiley, Whitney Fairchild, Anudeep K. Dodeja, Cesar I. Mesia, Caitlin M. Heyden, Shailendra Upadhyay   +5 more
doaj   +1 more source

Acute left ventricular dysfunction secondary to right ventricular septal pacing in a woman with initial preserved contractility: a case report

Journal of Medical Case Reports, 2011
Introduction Right ventricular apical pacing-related heart failure is reported in some patients after long-term pacing. The exact mechanism is not yet clear but may be related to left ventricular dyssynchrony induced by right ventricular apical pacing ...
Gribaa Rim, Neffeti Elyes, Lagren Afef, Kacem Slim, Azzez Soufiene, Ouali Sana, Remedi Fahmi, Boughzela Essia   +7 more
doaj   +1 more source

Quantitative analysis of cardiac left ventricular variables obtained by MRI at 3 T : a pre- and post-contrast comparison [PDF]

, 2012
Short-axis cine images are acquired during cardiac MRI in order to determine variables of cardiac left ventricular (LV) function such as ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and LV mass.
Crowe, E. A., J G Houston, Houston, J. G., Lerski, R. A., R S Nicholas, S Matthew, S J Gandy, Gandy, S. J., Nicholas, R. S., Dunn, M. H., R A Lerski, E A Crowe, Waugh, S. A., S A Waugh, Matthew, S., M H Dunn   +15 more
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Tissue Doppler imaging following paediatric cardiac surgery : early patterns of change and relationship to outcome [PDF]

, 2009
In this study, tissue Doppler imaging (TDI) was used to assess changes in ventricular function following repair of congenital heart defects. The relationship between TDI indices, myocardial injury and clinical outcome was explored.
MacArthur, Kenneth, Lyall, Fiona, Peng, Edward, The Association of Children with Heart Disorders (Funder), Vassalos, Antony, Young, David, Pollock, James, Danton, Mark H. D., Lilley, Stuart   +8 more
core   +4 more sources

Right Ventricular Function, Peripheral Edema, and Acute Kidney Injury in Critical Illness

Kidney International Reports, 2017
The cardiorenal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently. In a cohort of critically ill patients with echocardiographic measurements
Christina Chen, Joon Lee, Alistair E. Johnson, Roger G. Mark, Leo Anthony Celi, John Danziger   +5 more
doaj   +1 more source

Relationship between left ventricular mechanical synchrony and left ventricular systolic function: a CZT-SPECT analysis

BMC Cardiovascular Disorders, 2022
Background CZT-SPECT has good agreement in the evaluation of mechanical synchronization compared with conventional SPECT. The aim of this study was to evaluate the correlation between left ventricular mechanical contraction synchrony and left ventricular
Qiting Sun, Ruiliang Huang, Songhai Fu, Chen Wu, Xuliang Guo, Tianliang Li, Yuehong Hou, Fei Wang, Rui Xi, Sijin Li   +9 more
doaj   +1 more source