Results 161 to 170 of about 361,152 (309)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Patient-Specific Lumped-Parameter Model for Quantifying Vessel-Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension. [PDF]

Compr Physiol
Lechuga CG, Kachabi A, Colebank MJ, Korcarz CE, Raza F, Chesler NC.   +5 more
europepmc   +1 more source

Curvy Surface Reconstruction

Advanced Science, EarlyView.
This review introduces the concept of “general curvy surface reconstruction,” which incorporates both geometric and physical dimensions, representing an upgrade over conventional geometric reconstruction that focuses solely on spatial relationships. Particular emphasis is placed on the emerging opportunities enabled by advanced measurement techniques ...
Chen Shang, Haoyu Qi, Zhigang Wang, Keyu Meng, Zeye Liu, Zeng Meng, Yu Yang, Jianjun Wang, Shan Jiang   +8 more
wiley   +1 more source

Beta-Alanine Supplementation Ameliorates Right Ventricular Remodeling Caused by Monocrotaline-Induced Pulmonary Hypertension. [PDF]

Pulm Circ
Su H, Li B, Guo Z, Zhang F, Wang A, Jiang K, Zhu H, Yang Y, Zeng J, Li W, Cao Y, Liu J.   +11 more
europepmc   +1 more source

Arbitrary 3D Organic Mixed Ionic‐Electronic Conductor Architectures via Self‐Fusion of PEDOT:PSS Microfibers

Advanced Science, EarlyView.
A general fabricating strategy for arbitrary 3D organic mixed ionic‐electronic conductor architectures is reported using PEDOT:PSS microfiber building blocks. A water‐assisted self‐fusion process is successfully developed in which adhesion can be modulated as reversible (PSS‐rich) or irreversible (PEDOT‐rich) self‐fusion depending on the post‐treatment
Youngseok Kim, Jongwon Lee, Jiwoong Kim, Jung Il Yoo, Junggeon Park, Jaeyoung Lee, Heung Cho Ko, HyungJu Ahn, Myung‐Han Yoon   +8 more
wiley   +1 more source

The 24-Segment Global Sphericity Index Is Useful for Assessing Fetal Cardiac Function and as an Indicator of Fetal Well-Being. [PDF]

Cureus
Kogita H, Oyama R, Haba G, Kawamura H, Baba T.   +4 more
europepmc   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Ultrasound in Extracorporeal Membrane Oxygenation: An ELSO State-of-the-Art Review. [PDF]

ASAIO J
Douflé G, O'Neil ER, Abreu S, Aljassim NA, Di Nardo M, Obonyo NG, Pinzon V, Price S, Ramanathan K, Balik M.   +9 more
europepmc   +1 more source

Curved Bistable Origami‐Inspired Flexible Transcatheter Mitral Valve Clamping

Advanced Science, EarlyView.
A lightweight bistable curved origami dilator combines reversible deformation and high stability, offering a promising solution for minimally invasive mitral valve repair. Abstract Curved origami exhibits remarkable potential for minimally invasive medical applications owing to its unique geometric programmability and mechanical tunability. Building on
Siyu Gao, Fan Jiang, Xiuting Sun, Peng Qi, Jian Xu   +4 more
wiley   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source